Director, Professor, and Head; Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India.
Senior Resident, Department of Medicine, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India; Corresponding Author.
J Assoc Physicians India. 2022 Jun;70(6):11-12. doi: 10.5005/japi-11001-0007.
Nonalcoholic fatty liver disease (NAFLD) is a well-known contributor for the development of cardiovascular disease (CVD). Nonalcoholic fatty liver disease is considered as the liver component of metabolic syndrome (MetS). This study aimed to assess the influence of NAFLD and MetS on markers of subclinical atherosclerosis, including carotid intima-media thickness (CIMT), ankle-brachial pressure index (ABI), and to investigate the impact of NAFLD and MetS on left ventricular (LV) diastolic and systolic function.
A case-control study.
In this case-control study, 120 cases and 90 healthy controls in the age group ranging from ≥18 to ≤65 years were included. Metabolic syndrome was assessed using International Diabetes Federation (IDF) criteria. Height, weight, waist circumference, body mass index (BMI), and blood pressure were measured. Liver ultrasonographic scanning was used for assessing fatty liver. To assess atherosclerosis, CIMT and ABI were used.
The prevalence of NAFLD was 66.7%. As compared with control subjects, patients with NAFLD had a significantly greater (p = 0.02) mean CIMT while in patients with MetS, it was not significant. Left ventricular diastolic and systolic function were significantly impaired (p = 0.03, p = 0.04, respectively) in NAFLD while only LV diastolic function was significantly (p = 0.04) impaired in MetS. There was a strong positive correlation between CIMT and triglyceride (TG) (r = 0.46, p = 0.0001), total cholesterol (TC) (r = 0.47, p = 0.0001), low density lipoprotein cholesterol (LDL-C) (r = 0.46, p = 0.0001), very low density lipoprotein cholesterol (VLDL-C) (r = 0.259, p = 0.001), BMI (r = 0.21, p = 0.003), and age (r = 0.22, p = 0.002).
Carotid intima-media thickness, ABI, and LV diastolic function were affected in patients with NAFLD and MetS.
非酒精性脂肪性肝病（NAFLD）是心血管疾病（CVD）发展的一个众所周知的因素。非酒精性脂肪性肝病被认为是代谢综合征（MetS）的肝脏组成部分。本研究旨在评估 NAFLD 和 MetS 对亚临床动脉粥样硬化标志物的影响，包括颈动脉内膜中层厚度（CIMT）、踝臂血压指数（ABI），并探讨 NAFLD 和 MetS 对左心室（LV）舒张和收缩功能的影响。
病例对照研究。
在这项病例对照研究中，纳入了年龄在 18 岁至 65 岁之间的 120 例病例和 90 例健康对照者。使用国际糖尿病联合会（IDF）标准评估代谢综合征。测量身高、体重、腰围、体重指数（BMI）和血压。使用肝脏超声扫描评估脂肪肝。使用 CIMT 和 ABI 评估动脉粥样硬化。
NAFLD 的患病率为 66.7%。与对照组相比，NAFLD 患者的平均 CIMT 显著更高（p=0.02），而在 MetS 患者中则不显著。NAFLD 患者的左心室舒张和收缩功能明显受损（p=0.03，p=0.04），而 MetS 患者仅左心室舒张功能明显受损（p=0.04）。CIMT 与甘油三酯（TG）（r=0.46，p=0.0001）、总胆固醇（TC）（r=0.47，p=0.0001）、低密度脂蛋白胆固醇（LDL-C）（r=0.46，p=0.0001）、极低密度脂蛋白胆固醇（VLDL-C）（r=0.259，p=0.001）、BMI（r=0.21，p=0.003）和年龄（r=0.22，p=0.002）之间存在强正相关。
NAFLD 和 MetS 患者的颈动脉内膜中层厚度、ABI 和 LV 舒张功能受到影响。
