Guler Muhammet Akif, Laloglu Fuat, Orbak Zerrin, Ceviz Naci, Islek Ali
Division of Pediatric Nephrology, Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Division of Pediatric Cardiology, Department of Pediatrics, Atatürk University Faculty of Medicine, Erzurum, Turkey.
Eurasian J Med. 2022 Jun;54(2):173-180. doi: 10.5152/eurasianjmed.2022.21083.
Compared to adult studies, there are few epidemiological and clinical reports on coronavirus disease 2019 in children. We aimed to present the demographic, epidemiological, and clinical findings of hospitalized pediatric coronavirus disease 2019 patients.
Patients aged 0-18 years who were hospitalized between March and July 2020 due to severe acute respiratory syndrome coronavirus 2 infection were evaluated retrospectively.
The mean age was 90.2 ± 67.5 (7-24) months and 23 (51%) were female. Clinical presentation was asymptomatic in 15 cases (33.3%), mild/moderate in 26 cases (57.8%), and severe/critical in 4 cases (8.9%). Three (6.6%) of the patients had chronic medical conditions that placed them in the high-risk group for coronavirus disease 2019. The source of infection was household transmission in 29 cases (64.4%). The most common symptoms were cough, fever, and fatigue. Mean serum lactate, C-reactive protein (CRP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels were significantly higher in severe/criti- cal patients compared to the other two groups (P < .05). severe acute respiratory syndrome coronavirus 2 negativity in control swabs (n=26) occurred at a mean of 10.6 ± 2.9 days after symptom onset. Forty-three patients (95.6%) were followed in the ward and 2 (4.4%) were admitted to the intensive care unit.
Children aged 0-18 years constituted a very small proportion of coronavirus disease 2019 reverse transcription-polymerase chain reaction -positive cases. Asymptomatic carriage of SARS- CoV-2 by a large proportion of children seems to be a major factor driving community spread. Some children with coronavirus disease 2019 may also present neurological findings. coronavirus disease 2019 infection is more severe in patients with comorbidities, and support therapy is important in these patients.
与成人研究相比，关于2019冠状病毒病在儿童中的流行病学和临床报告较少。我们旨在呈现住院的2019冠状病毒病儿科患者的人口统计学、流行病学和临床特征。
对2020年3月至7月因严重急性呼吸综合征冠状病毒2感染而住院的0至18岁患者进行回顾性评估。
平均年龄为90.2±67.5（7至24）个月，23例（51%）为女性。临床表现为无症状的有15例（33.3%），轻度/中度的有26例（57.8%），重度/危重症的有4例（8.9%）。3例（6.6%）患者有慢性疾病，使其属于2019冠状病毒病的高危人群。感染源为家庭传播的有29例（64.4%）。最常见的症状是咳嗽、发热和乏力。与其他两组相比，重度/危重症患者的平均血清乳酸、C反应蛋白（CRP）、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平显著更高（P<0.05）。对照拭子（n = 26）中严重急性呼吸综合征冠状病毒2转阴的平均时间为症状出现后10.6±2.9天。43例患者（95.6%）在病房接受随访，2例（4.4%）入住重症监护病房。
0至18岁儿童在2019冠状病毒病逆转录-聚合酶链反应阳性病例中占比非常小。很大一部分儿童无症状携带严重急性呼吸综合征冠状病毒2似乎是推动社区传播的主要因素。一些2019冠状病毒病儿童患者也可能出现神经系统表现。2019冠状病毒病感染在合并症患者中更为严重，对这些患者进行支持治疗很重要。
