Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.
Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.
Invest Ophthalmol Vis Sci. 2022 Feb 1;63(2):34. doi: 10.1167/iovs.63.2.34.
To identify the association between the choroidal thickness (ChT) with age and axial length (AL) under different refractive errors (REs) in Chinese adults.
Swept-source optical coherence tomography was used to measure ChT in 2126 right eyes of 2126 participants. The participants were classified as having pathologic myopia (PM), high myopia without PM (HM), low myopia (LM), and nonmyopia (non-M) according to their REs and META-PM (the Meta-Analysis of Pathologic Myopia) classification criteria.
The mean age was 52.49 ± 20.39 years (range, 18-93 years), and the mean RE was -5.27 ± 5.37 diopters (D; range, -25.5 to +7.75 D). The mean average ChT was 159.25 ± 80.75 µm and decreased in a linear relationship from non-M to PM (190.04 ± 72.64 µm to 60.99 ± 37.58 µm, P < 0.001). A significant decline in ChT was noted between 50 and 70 years (r = -0.302, P < 0.001) and less rapidly after the age of 70 years (r = -0.105, P = 0.024). No correlation was noted between age and ChT under 50 years (P = 0.260). A significantly higher association with AL was noted in the central fovea (βHM = -23.92, βLM = -23.88, βNon-M = -18.80, all P < 0.001) and parafoveal ChT (βHM = -22.87, βLM = -22.31, βNon-M = -18.61, all P < 0.001) when compared with the perifoveal region (βHM = -19.80, βLM = -18.29, βNon-M = -13.95, all P < 0.001). Within each group of PM, HM, LM, and non-M, regression analysis showed that the coefficients of age and AL with different macular regions of ChT varied significantly.
ChT was negatively correlated with age after 50 years. The thinning of the choroid was more prominent in the center and parafoveal regions as AL increased. Varied distributions of ChT decrease associated with AL and age were noted among different refractive groups.
在中国成年人中，根据不同的屈光不正（RE）和眼轴（AL），确定脉络膜厚度（ChT）与年龄的关系。
使用扫频源光学相干断层扫描（OCT）对 2126 名参与者的 2126 只右眼进行 ChT 测量。根据其 RE 和 META-PM（病理性近视的荟萃分析）分类标准，参与者被分为病理性近视（PM）、高度近视无 PM（HM）、低度近视（LM）和非近视（非-M）。
平均年龄为 52.49 ± 20.39 岁（18-93 岁），平均 RE 为-5.27 ± 5.37 屈光度（D；范围-25.5 至+7.75 D）。平均平均 ChT 为 159.25 ± 80.75 µm，从非-M 到 PM（190.04 ± 72.64 µm 到 60.99 ± 37.58 µm，P < 0.001）呈线性下降。在 50 至 70 岁之间，ChT 显著下降（r = -0.302，P < 0.001），70 岁后下降速度较慢（r = -0.105，P = 0.024）。在 50 岁以下，年龄与 ChT 之间无相关性（P = 0.260）。在中央凹（βHM = -23.92，βLM = -23.88，βNon-M = -18.80，均 P < 0.001）和旁中心凹 ChT（βHM = -22.87，βLM = -22.31，βNon-M = -18.61，均 P < 0.001）中，与旁中心凹区域相比（βHM = -19.80，βLM = -18.29，βNon-M = -13.95，均 P < 0.001），脉络膜厚度与 AL 的相关性更高。在 PM、HM、LM 和非-M 每组中，回归分析表明，年龄和 AL 与脉络膜不同黄斑区域的 ChT 系数差异显著。
50 岁后，ChT 与年龄呈负相关。脉络膜变薄在中央和旁中心区域更为明显，随着 AL 的增加而增加。在不同的屈光组中，ChT 与 AL 和年龄的下降分布不同。
