志贺毒素对人结肠和回肠上皮细胞原代培养物的细胞毒性。
Cytotoxicity of Shiga toxin for primary cultures of human colonic and ileal epithelial cells.
作者信息
Moyer M P, Dixon P S, Rothman S W, Brown J E
出版信息
Infect Immun. 1987 Jun;55(6):1533-5. doi: 10.1128/iai.55.6.1533-1535.1987.
Abstract
Shiga toxin purified from Shigella dysenteriae 1 was cytotoxic to cultured epithelial cells from human colon and ileum. The cytotoxicity, which affected only about 50% of treated cells, was neutralized by rabbit antiserum monospecific for Shiga toxin and mediated by protein synthesis inhibition.
摘要
从痢疾志贺氏菌1型中纯化出的志贺毒素对人结肠和回肠的培养上皮细胞具有细胞毒性。这种细胞毒性仅影响约50%的处理细胞，可被针对志贺毒素的兔单特异性抗血清中和，并由蛋白质合成抑制介导。
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