溴化亚铜催化芳烃与N-羟基邻苯二甲酰亚胺的直接C-H胺化反应。
Direct C-H amination reactions of arenes with -hydroxyphthalimides catalyzed by cuprous bromide.
作者信息
Zhang Dongming, Lv Bin, Gao Pan, Jia Xiaodong, Yuan Yu
机构信息
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. of China.
出版信息
Beilstein J Org Chem. 2022 Jun 3;18:647-652. doi: 10.3762/bjoc.18.65. eCollection 2022.
Abstract
An efficient Cu-catalyzed strategy for the direct C-H amination of arenes in high yields using -hydroxyphthalimide as the amidyl radical precursor under air is reported. A possible mechanism is proposed that proceeds via a radical reaction in the presence of CuBr and triethyl phosphite.
摘要
报道了一种高效的铜催化策略，该策略可在空气中以邻羟基苯二甲酰亚胺作为酰胺基自由基前体，高产率地实现芳烃的直接C-H胺化反应。提出了一种可能的机理，该机理是在溴化铜和亚磷酸三乙酯存在下通过自由基反应进行的。
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