Feng Yuqing, Liu Dan, Liu Yan, Yang Xinyue, Zhang Meihong, Wei Fuxiao, Li Depeng, Hu Yongfei, Guo Yuming
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, PR China.
iScience. 2022 May 26;25(6):104469. doi: 10.1016/j.isci.2022.104469. eCollection 2022 Jun 17.
In chickens, the effect of host genetics on the gut microbiota is not fully understood, and the extent to which the heritable gut microbes affect chicken metabolism and physiology is still an open question. Here, we explored the interactions among chicken genetics, the cecal microbiota and metabolites in breast muscle from ten chicken breeds in China. We found that different chicken breeds displayed distinct cecal microbial community structures and functions, and 15 amplicon sequence variants (ASVs) were significantly associated with host genetics through different genetic loci, such as those related to the intestinal barrier function. We identified five heritable ASVs significantly associated with 53 chicken muscle metabolites, among which the probably affected lipid metabolism through the production of propionate. Our study revealed that the chicken genetically associated cecal microbes may have the potential to affect the bird's physiology and metabolism.
在鸡中，宿主基因对肠道微生物群的影响尚未完全了解，可遗传的肠道微生物影响鸡的代谢和生理机能的程度仍是一个悬而未决的问题。在此，我们探究了中国十个鸡品种的鸡基因、盲肠微生物群和胸肌中代谢物之间的相互作用。我们发现，不同鸡品种表现出不同的盲肠微生物群落结构和功能，并且15个扩增子序列变体（ASV）通过不同的基因位点与宿主基因显著相关，例如那些与肠道屏障功能相关的位点。我们鉴定出五个与53种鸡肌肉代谢物显著相关的可遗传ASV，其中可能通过丙酸的产生影响脂质代谢。我们的研究表明，与鸡基因相关的盲肠微生物可能有影响鸡的生理机能和代谢的潜力。
