State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
mSystems. 2023 Dec 21;8(6):e0084423. doi: 10.1128/msystems.00844-23. Epub 2023 Nov 29.
The improvement of chicken growth performance is one of the major concerns for the poultry industry. Gut microbes are increasingly evidenced to be associated with chicken physiology and metabolism, thereby influencing chicken growth and development. Here, through integrated multi-omics analyses, we showed that chickens from the same line differing in their body weight were very different in their gut microbiota structure and host-microbiota crosstalk; microbes in high body weight (HBW) chickens contributed to chicken growth by regulating the gut function and homeostasis. We also verified that a specific bacterial consortium consisting of isolates from the HBW chickens has the potential to be used as chicken growth promoters. These findings provide new insights into the potential links between gut microbiota and chicken phenotypes, shedding light on future manipulation of chicken gut microbiota to improve chicken growth performance.
提高鸡的生长性能是家禽业关注的主要问题之一。越来越多的证据表明，肠道微生物与鸡的生理和代谢有关，从而影响鸡的生长和发育。在这里，通过综合多组学分析，我们发现同一系但体重不同的鸡的肠道微生物结构和宿主-微生物相互作用有很大的不同；高体重（HBW）鸡中的微生物通过调节肠道功能和稳态来促进鸡的生长。我们还验证了由 HBW 鸡分离株组成的特定细菌联合体具有作为鸡生长促进剂的潜力。这些发现为肠道微生物群与鸡表型之间的潜在联系提供了新的见解，为未来通过操纵鸡的肠道微生物群来提高鸡的生长性能提供了思路。
