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靶向治疗巨噬细胞可塑性重塑肿瘤免疫微环境。

Therapeutic Targeting of Macrophage Plasticity Remodels the Tumor-Immune Microenvironment.

机构信息

Systems Onco-Immunology Laboratory, The David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Department of Pathology/Laboratory Medicine, Division of Pathology/Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.

出版信息

Cancer Res. 2022 Jul 18;82(14):2593-2609. doi: 10.1158/0008-5472.CAN-21-3506.

DOI:10.1158/0008-5472.CAN-21-3506
PMID:35709756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9296613/
Abstract

Comprehensive single-cell proteomics analyses of lung adenocarcinoma progression reveal the role of tumor-associated macrophages in resistance to PD-1 blockade therapy. See related commentary by Lee et al., p. 2515.

摘要

全面的单细胞蛋白质组学分析揭示了肺腺癌进展中肿瘤相关巨噬细胞在 PD-1 阻断治疗耐药中的作用。详见 Lee 等人的相关述评，第 2515 页。

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Cancer Stem Cells-Origins and Biomarkers: Perspectives for Targeted Personalized Therapies.癌症干细胞的起源和生物标志物：靶向个体化治疗的新视角。
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