GTP 在控制细胞表型中的区室化和调节。
Compartmentalization and regulation of GTP in control of cellular phenotypes.
机构信息
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.
Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
出版信息
Trends Mol Med. 2022 Sep;28(9):758-769. doi: 10.1016/j.molmed.2022.05.012. Epub 2022 Jun 16.
Abstract
Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current Review, we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.
摘要
遗传或药理学抑制参与 GTP 生物合成的酶具有显著的生物学效应，这凸显了更好地理解 GTP 水平在细胞过程调节中的作用以及针对 GTP 生物合成酶进行治疗干预的重要性。我们目前对于 GTP 代谢的时空调节及其在生理和病理细胞过程中的作用的理解还远远不够。新型方法，如游离 GTP 的基因编码传感器，提供了对 GTP 分子在细胞内分布和功能的深入了解。在本期综述中，我们对 GTP 代谢领域的最新发现进行了分析，并评估了关键酶作为分子靶标。
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