Bogariu Alina M, Dumitrascu Dan L
2 Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Med Pharm Rep. 2022 Jan;95(1):5-10. doi: 10.15386/mpr-2340. Epub 2022 Jan 31.
The SARS-CoV-2 infection which caused a worldwide epidemic was considered first a lung disease. Later on, it was found that the disease caused by this virus, SARS-CoV-2, can affect most organs, including the digestive system. The long-term effects of this infection are now progressively detected and called Long-COVID. This review aims is to present the updated knowledge of the digestive sequelae after SARS-CoV-2 infection.
A search was performed in the main medical literature databases. The following search terms were used: long-covid, gastrointestinal or gastric sequelae SARS-CoV-2 and COVID-19. Data on gastrointestinal symptoms after 12 weeks were collected and presented. Observational studies were included. Studies that focus only on acute COVID-19 infection (<4 weeks) were excluded.
The main symptoms that can occur in the long term are: diarrhea, nausea, vomiting, abdominal pain, along with increased liver enzymes. Patients with chronic diseases have a higher risk of developing long-term sequelae, but it is not documented that digestive sequelae are influenced by the presence of chronic diseases.
The SARS-CoV-2 virus can affect any part of the digestive system not only in the acute infection phase but also for longer time, leaving long-term sequelae.
导致全球大流行的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染最初被认为是一种肺部疾病。后来发现，这种由SARS-CoV-2病毒引起的疾病可影响包括消化系统在内的大多数器官。目前，这种感染的长期影响正逐渐被发现，并被称为“长新冠”。本综述旨在介绍SARS-CoV-2感染后消化系统后遗症的最新知识。
在主要医学文献数据库中进行检索。使用了以下检索词：长新冠、胃肠道或胃部后遗症、SARS-CoV-2和2019冠状病毒病。收集并呈现了12周后胃肠道症状的数据。纳入了观察性研究。仅关注急性2019冠状病毒病感染（<4周）的研究被排除。
长期可能出现的主要症状有：腹泻、恶心、呕吐、腹痛，以及肝酶升高。慢性病患者发生长期后遗症的风险更高，但尚无文献证明消化系统后遗症受慢性病的影响。
SARS-CoV-2病毒不仅在急性感染期，而且在更长时间内都可影响消化系统的任何部位，留下长期后遗症。
