Almas Talal, Malik Jahanzeb, Alsubai Abdulla K, Jawad Zaidi Syed Muhammad, Iqbal Raafe, Khan Kashif, Ali Muhammad, Ishaq Uzma, Alsufyani Majid, Hadeed Sebastian, Alsufyani Reema, Ahmed Reema, Thakur Tushar, Huang Helen, Antony Meetty, Antony Ishan, Bhullar Anhad, Kotait Farida, Al-Ani Lubabah
Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, 46000, Pakistan.
Ann Med Surg (Lond). 2022 Aug;80:103995. doi: 10.1016/j.amsu.2022.103995. Epub 2022 Jun 15.
This systematic review aimed at estimating the prevalence of post-acute COVID-19 symptoms in view of published literature that studied prolonged clinical manifestations after recovery from acute COVID-19 infection.
Relevant databases were searched for extraction of articles. For data synthesis, based on the distribution of quantitative variables, they were expressed as mean ± standard deviation (SD) or median and interquartile range (IQR). Qualitative variables were presented as frequency (n) and percentages (%).
Twenty-one articles qualified for the final analysis. The most common persistent clinical manifestations were fatigue (54.11%), dyspnea (24.38%), alopecia (23.21%), hyperhidrosis (23.6%), insomnia (25.98%), anxiety (17.29%), and arthralgia (16.35%). In addition to these symptoms, new-onset hypertension, diabetes, neuropsychiatric disorders, and bladder incontinence were also reported.
Clinical features of post-acute COVID-19 infection can manifest even after 60 days of initial infection. Multidisciplinary care along with regular follow-up must be provided to such patients.
鉴于已发表的关于急性 COVID-19 感染康复后长期临床表现的文献，本系统评价旨在估计急性 COVID-19 后症状的患病率。
检索相关数据库以提取文章。对于数据综合，根据定量变量的分布，将其表示为均值±标准差（SD）或中位数和四分位间距（IQR）。定性变量以频率（n）和百分比（%）表示。
21 篇文章符合最终分析要求。最常见的持续临床表现为疲劳（54.11%）、呼吸困难（24.38%）、脱发（23.21%）、多汗（23.6%）、失眠（25.98%）、焦虑（17.29%）和关节痛（16.35%）。除这些症状外，还报告了新发高血压、糖尿病、神经精神障碍和膀胱失禁。
急性 COVID-19 感染后的临床特征甚至可在初次感染 60 天后出现。必须为这类患者提供多学科护理及定期随访。
