Department of Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.
Department of Public Health, National University of Medical Sciences, Saddar, Rawalpindi, Pakistan.
PLoS One. 2021 Mar 30;16(3):e0249421. doi: 10.1371/journal.pone.0249421. eCollection 2021.
Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result.
Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT.
Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease.
This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
2019 年冠状病毒病（COVID-19）是一种持续流行的疾病，对人体的生理平衡有多种长期影响。它也可能对甲状腺功能产生多种影响。我们旨在评估 COVID-19 对甲状腺激素的持久后遗症以及由此导致的疾病临床过程。
在 76 名患者中，对 48 名 COVID-19 阳性患者和 28 名 COVID-19 阴性聚合酶链反应（PCR）患者的甲状腺功能、IL-6 和降钙素原进行评估，这些患者在 HRCT 上分别患有中度、重度和危重症肺炎。
75%的 COVID-19 患者存在甲状腺异常和更高的 IL-6 水平（76.10 ± 82.35 与 6.99 ± 3.99，95%CI 52.18-100.01，P 值 <0.01）。逻辑回归分析表明 TT3（P 值 0.01）、IL-6（P 值 <0.01）和降钙素原（P 值 0.03）是 COVID-19 的独立危险因素。ROC 曲线表明 IL-6 是最敏感的标志物（P 值 <0.01），TT3 和降钙素原是 COVID-19 疾病的预测指标。
这项来自巴基斯坦的初步研究表明，血清 TSH 和 TT3 水平的变化可能是 COVID-19 肺炎病程的重要表现。
