Mechanisms for the Invasion and Dissemination of .

is a gastroenteric Gram-negative bacterium that can infect both humans and animals and causes millions of illnesses per year around the world. infections usually occur after the consumption of contaminated food or water. Infections with species can cause diseases ranging from enterocolitis to typhoid fever. has developed multiple strategies to invade and establish a systemic infection in the host. Different cell types, including epithelial cells, macrophages, dendritic cells, and M cells, are important in the infection process of . Dissemination throughout the body and colonization of remote organs are hallmarks of infection. There are several routes for the dissemination of typhimurium. This review summarizes the current understanding of the infection mechanisms of . Additionally, different routes of infection will be discussed. In this review, the strategies used by enterica to establish persistent infection will be discussed. Understanding both the bacterial and host factors leading to the successful colonization of may enable the rational design of effective therapeutic strategies.