Kiorpes L, Boothe R G, Hendrickson A E, Movshon J A, Eggers H M, Gizzi M S
J Neurosci. 1987 May;7(5):1318-26. doi: 10.1523/JNEUROSCI.07-05-01318.1987.
We raised 8 macaque monkeys with chronic atropinization of one eye throughout the first 6-10 months after birth. This rearing procedure produces retinal image blur, with the most pronounced contrast attenuation occurring at high spatial frequencies. Measurements of contrast sensitivity were made using behavioral methods in 6 monkeys and evoked potential methods in 2 monkeys. The results showed that this rearing procedure produced long-term deficits in the contrast sensitivity and spatial resolution of the atropinized eye, which were not due to residual losses in accommodative capacity. There was considerable interanimal variation in the magnitude of the effects on visual performance. Similar losses in visual performance are seen in some forms of human amblyopia. Rearing monkeys with chronic instillation of atropine therefore provides a nonhuman primate model for studying the underlying neural mechanisms of anisometropic amblyopia.
在出生后的头6至10个月，我们饲养了8只恒河猴，其中一只眼睛长期处于阿托品化状态。这种饲养方式会导致视网膜图像模糊，在高空间频率下对比度衰减最为明显。对6只猴子使用行为学方法、2只猴子使用诱发电位方法进行了对比敏感度测量。结果表明，这种饲养方式会导致阿托品化眼睛的对比敏感度和空间分辨率长期受损，这并非由于调节能力的残余损失所致。对视觉性能的影响程度在动物个体之间存在相当大的差异。在某些形式的人类弱视中也观察到了类似的视觉性能损失。因此，长期给猴子滴注阿托品为研究屈光参差性弱视的潜在神经机制提供了一个非人类灵长类动物模型。
