Smith E L, Harwerth R S, Crawford M L
Invest Ophthalmol Vis Sci. 1985 Mar;26(3):330-42.
An anisometropia was simulated in infant rhesus monkeys by securing a high-powered minus lens (-10 D) in front of one eye. The anisometropia rearing procedure was initiated at 30 days of age and was continued for durations of 30, 60, or 90 days. Behavioral measurements of spatial contrast sensitivity obtained when the animals were 9 months of age indicated that the monkeys treated for 30 days had equal or nearly equal contrast sensitivities and cut-off spatial frequencies in the two eyes. The 30-day monkeys also demonstrated normal binocular summation for threshold stimuli. In contrast, the monkeys treated for either 60 or 90 days showed a significant reduction in contrast sensitivity in the defocused eyes for spatial frequencies greater than 1.0 cycles/deg and failed to show an improvement in contrast sensitivity under binocular viewing conditions. The cut-off spatial frequencies obtained at moderate luminance levels for the defocused eyes of the 60- and 90-day monkeys were slightly more than 1.0 octave lower than the cut-offs for the nondeprived eyes and, like humans with anisometropic amblyopia, the deficits in the spatial resolving capacity of the defocused eyes were observed over a large range of background luminances. The results indicate that the lens-reared monkey is a promising model for anisometropic amblyopia in humans.
通过在幼年恒河猴的一只眼前固定一个高屈光度的负透镜（-10 D）来模拟屈光参差。屈光参差饲养程序在30日龄时开始，并持续30、60或90天。当动物9个月大时获得的空间对比敏感度的行为测量结果表明，接受30天治疗的猴子双眼的对比敏感度和截止空间频率相等或几乎相等。接受30天治疗的猴子对阈值刺激也表现出正常的双眼总和。相比之下，接受60天或90天治疗的猴子在空间频率大于1.0周/度时，散焦眼的对比敏感度显著降低，并且在双眼观察条件下对比敏感度没有改善。60天和90天猴子散焦眼在中等亮度水平下获得的截止空间频率比未剥夺眼的截止频率低略超过1.0倍频程，并且与患有屈光参差性弱视的人类一样，在大范围的背景亮度下都观察到了散焦眼空间分辨能力的缺陷。结果表明，晶状体饲养的猴子是人类屈光参差性弱视的一个有前景的模型。
