School of Life Science and Engineering, Foshan University, Foshan, China.
Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
J Med Virol. 2022 Oct;94(10):5051-5055. doi: 10.1002/jmv.27949. Epub 2022 Jul 1.
The coronavirus disease 2019 (COVID-19) pandemic caused by the coronavirus severe acute respiratory syndrome coronavirus 2 remains risky worldwide. We elucidate here that good IDM (isolation, disinfection, and maintenance of health) is powerful to reduce COVID-19 deaths based on the striking differences in COVID-19 case fatality rates among various scenarios. IDM means keeping COVID-19 cases away from each other and from other people, disinfecting their living environments, and maintaining their health through good nutrition, rest, and treatment of symptoms and pre-existing diseases (not through specific antiviral therapy). Good IDM could reduce COVID-19 deaths by more than 85% in 2020 and more than 99% in 2022. This is consistent with the fact that good IDM can minimize co-infections and maintain body functions and the fact that COVID-19 has become less pathogenic (this fact was supported with three novel data in this report). Although IDM has been frequently implemented worldwide to some degree, IDM has not been highlighted sufficiently. Good IDM is relative, nonspecific, flexible, and feasible in many countries, and can reduce deaths of some other relatively mild infectious diseases. IDM, vaccines, and antivirals aid each other to reduce COVID-19 deaths. The IDM concept and strategy can aid people to improve their health behavior and fight against COVID-19 and future pandemics worldwide.
新型冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2 型引起的全球大流行疾病，目前仍具有较高的风险性。本研究通过分析不同场景下 COVID-19 病死率的显著差异，阐明了良好的综合传染病防控措施（隔离、消毒和保持健康）对降低 COVID-19 死亡率具有重要作用。IDM 是指通过保持社交距离、对生活环境进行消毒、通过良好的营养、休息和对症状及基础疾病的治疗来保持健康（而不是通过特定的抗病毒治疗），从而避免 COVID-19 患者及其密切接触者感染他人。在 2020 年和 2022 年，良好的 IDM 可分别降低超过 85%和 99%的 COVID-19 死亡率。这与 IDM 可最大限度减少合并感染和维持身体机能的事实以及 COVID-19 致病性降低的事实相一致（本报告中提供了三个新数据来支持这一事实）。尽管 IDM 在全球范围内已经在一定程度上得到了广泛应用，但仍未得到足够的重视。IDM 是相对的、非特异性的、灵活的、在许多国家都是可行的，并且可以降低一些其他相对温和的传染病的死亡率。IDM、疫苗和抗病毒药物可以相互配合，以降低 COVID-19 的死亡率。IDM 的概念和策略可以帮助人们改善健康行为，共同抗击 COVID-19 及其未来在全球范围内的大流行。
