The Sussex Eye Hospital, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.
South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, SA, Australia.
Eye (Lond). 2023 Apr;37(5):849-857. doi: 10.1038/s41433-022-02124-0. Epub 2022 Jun 21.
Caruncle malignancy is rare, but signs of disease can be easily missed by both patients and clinicians. There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Malignant diagnoses include lymphoproliferative disease, basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma and malignant melanoma. Increased pigmentation is associated with melanoma, yellow coloured deposition with sebaceous carcinoma and a salmon-pink hue with lymphoproliferative disease. Treatment involves excision with margin control which may necessitate exenteration. Metastases to cervical and preauricular lymph nodes has been reported.
结膜良性肿瘤罕见，但疾病迹象可能容易被患者和临床医生忽视。由于诊断和治疗延误，可能会导致严重的发病率，甚至死亡率。原发性恶性肿瘤的临床特征包括快速生长、色素沉积、溃疡表面和出血。恶性诊断包括淋巴增生性疾病、基底细胞癌、鳞状细胞癌、皮脂腺癌和恶性黑色素瘤。色素沉着增加与黑色素瘤有关，黄色沉积物与皮脂腺癌有关，鲑鱼粉红色色调与淋巴增生性疾病有关。治疗包括边缘控制的切除，可能需要进行眼眶内容剜除术。已经报道了颈部和耳前淋巴结转移。
