Chen Qun, Li Jiajia, Shen Peng, Yuan Hao, Yin Jie, Ge Wanli, Wang Wujun, Chen Guangbin, Yang Taoyue, Xiao Bin, Miao Yi, Lu Zipeng, Wu Pengfei, Jiang Kuirong
Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Affiliated Hospital of Yangzhou University, Yangzhou, China.
Cell Biosci. 2022 Jun 21;12(1):97. doi: 10.1186/s13578-022-00833-3.
Pancreatic cancer (PC) is a highly malignant solid tumor with insidious onset and easy early metastasis. Despite tremendous efforts devoted to research in this field, the mechanisms underlying PC tumorigenesis and progression remain unclear. Additionally, robust biomarkers and satisfactory therapeutic strategies for clinical use in PC patients are still lacking. Circular RNAs (circRNAs) are a new type of non-coding RNA originating from precursor messenger RNAs, with a covalent continuous closed-loop structure, strong stability and high specificity. Accumulating evidence suggests that circRNAs may participate in PC development and progression. Abnormal expression of circRNAs in PC is considered a vital factor that affects tumor cell proliferation, migration, invasion, apoptosis, angiogenesis and drug resistance. In this review of relevant articles published in recent years, we describe the basic knowledge concerning circRNAs, including their classification, biogenesis, functions and research approaches. Moreover, the biological roles and clinical significance of circRNAs related to PC are discussed. Finally, we note the questions remaining from recent studies and anticipate that further investigations will address these gaps in knowledge in this field. In conclusion, we expect to provide insights into circRNAs as potential targets for specific PC diagnosis and treatment in the future.
胰腺癌（PC）是一种恶性程度很高的实体瘤，起病隐匿，早期易转移。尽管在该领域的研究投入了巨大努力，但PC肿瘤发生和进展的潜在机制仍不清楚。此外，仍缺乏用于PC患者临床的可靠生物标志物和令人满意的治疗策略。环状RNA（circRNAs）是一种新型的非编码RNA，来源于前体信使RNA，具有共价连续闭环结构、强稳定性和高特异性。越来越多的证据表明，circRNAs可能参与PC的发生和进展。PC中circRNAs的异常表达被认为是影响肿瘤细胞增殖、迁移、侵袭、凋亡、血管生成和耐药性的重要因素。在这篇对近年来发表的相关文章的综述中，我们描述了关于circRNAs的基本知识，包括它们的分类、生物发生、功能和研究方法。此外，还讨论了与PC相关的circRNAs的生物学作用和临床意义。最后，我们指出了近期研究中存在的问题，并预计进一步的研究将填补该领域的这些知识空白。总之，我们期望为circRNAs作为未来PC特异性诊断和治疗的潜在靶点提供见解。
