1Center for Disease Control and Prevention, Institute of Public Health, Sombor, Serbia; Histopathology Department, Norfolk and Norwich University Hospital, United Kingdom; 2Queen Margaret University Edinburgh, United Kingdom; Faculty of Medicine, University of Novi Sad, Institute of Public Health of Vojvodina, Novi Sad, Serbia; 3Department of Ophthalmology, James Paget University Hospitals, Gorleston-on-Sea, United Kingdom; 4Faculty of Pharmacy of Novi Sad, University Business Academy in Novi Sad, Serbia; 5Department of Infectious Diseases, University Clinical Centre of Vojvodina; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 6Department of Neurology, University Clinical Centre of Vojvodina; Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Acta Clin Croat. 2021 Dec;60(4):579-589. doi: 10.20471/acc.2021.60.04.03.
The objective of this study was to investigate the prevalence of depression and anxiety among patients with chronic hepatitis C and how depression and anxiety correlate with respective health-related quality of life (HRQoL) domains, sociodemographic factors, and clinico-epidemiological characteristics. This prospective study involved 150 patients with chronic hepatitis C awaiting interferon treatment for hepatitis C and 150 healthy subjects. All individuals enrolled in the study completed the Short Form 36 (SF-36) questionnaire and Hospital Anxiety Depression Scale. The symptoms showed greater severity/score among patients with chronic hepatitis C for both depression (t=3.37; p<0.01) and anxiety (t=2.35; p<0.05). Regression analysis was used for estimating the relationship between depression and the set of predictors (domains of the SF-36 questionnaire). Three HRQoL domains (Physical Functioning, Vitality, and Mental Health) were found to have the strongest predictive contribution to the occurrence of depression. A series of Kruskal-Wallis and Mann-Whitney tests showed a significant difference in depression level between marital status categories (χ(2)=7.86, p<0.05). Divorced participants had significantly higher scores compared to married participants (Z=-2.40, p<0.05) and single participants (Z=-2.75, p<0.01). Unemployment was associated with a higher degree of depression and anxiety. There was no association identified between duration of the disease, route of hepatitis C virus transmission, existence of cirrhosis, and depression or anxiety. The findings of this study can assist in developing a standard protocol for the management of chronic hepatitis C that will include psychological assessment and support.
本研究旨在调查慢性丙型肝炎患者中抑郁和焦虑的患病率，以及抑郁和焦虑与各自的健康相关生活质量（HRQoL）领域、社会人口学因素和临床流行病学特征的相关性。这项前瞻性研究涉及 150 名等待干扰素治疗丙型肝炎的慢性丙型肝炎患者和 150 名健康对照者。所有入组研究的个体均完成了简明 36 项健康调查量表（SF-36）和医院焦虑抑郁量表。对于抑郁（t=3.37;p<0.01）和焦虑（t=2.35;p<0.05），慢性丙型肝炎患者的症状表现出更大的严重程度/评分。回归分析用于估计抑郁与一组预测因子（SF-36 问卷的各个领域）之间的关系。发现三个 HRQoL 领域（身体功能、活力和心理健康）对抑郁的发生具有最强的预测贡献。一系列克鲁斯卡尔-沃利斯和曼-惠特尼检验显示，在婚姻状况类别之间抑郁水平存在显著差异（χ(2)=7.86,p<0.05）。与已婚参与者（Z=-2.40,p<0.05）和单身参与者（Z=-2.75,p<0.01）相比，离异参与者的得分显著更高。失业与更高程度的抑郁和焦虑相关。未发现疾病持续时间、丙型肝炎病毒传播途径、肝硬化的存在与抑郁或焦虑之间存在关联。本研究的结果可以帮助制定慢性丙型肝炎管理的标准方案，其中包括心理评估和支持。
