Adelson School of Medicine, Ariel University, Ariel, Israel.
Isr Med Assoc J. 2022 Jun;24(6):353-356.
The development of antibiotic agents has revolutionized the treatment of infectious diseases and clinical practice. However, antibiotic overuse, together with biologic evolution, has resulted in escalating antibiotic resistance of bacteria; with the One Health concept, it affects our planet including animals, aquatic wildlife, rivers, groundwater, lakes, sea water, aqua farming, and soil. This situation threatens our ability to treat infections effectively in the near future and raises the alarming question of whether we are getting close to the post-antibiotic era. Several measures are suggested to prevent the apocalyptic consequence of antibiotic overuse, few of which are novel with thinking outside the box.
抗生素的发展彻底改变了传染病的治疗和临床实践。然而，抗生素的过度使用，加上生物进化，导致了细菌对抗生素的耐药性不断升级；从“同一健康”的角度来看，它影响了我们的地球，包括动物、水生野生动物、河流、地下水、湖泊、海水、水产养殖和土壤。这种情况威胁到我们在不久的将来有效治疗感染的能力，并提出了一个令人震惊的问题，即我们是否接近后抗生素时代。已经提出了一些措施来预防抗生素过度使用的灾难性后果，其中少数是新颖的，需要跳出固有思维。
