基于 ZIF-67/AgNWs 纳米复合材料的叶酸灵敏稳定电化学传感器的构建。

Sensitive and Stable Electrochemical Sensor for Folic Acid Determination Using a ZIF-67/AgNWs Nanocomposite.

机构信息

Beijing Laboratory of Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

Department of Nutrition and Health, China Agricultural University, Beijing 100091, China.

出版信息

Biosensors (Basel). 2022 May 31;12(6):382. doi: 10.3390/bios12060382.

An electrochemical sensor using silver nanowires (AgNWs)-doped with a zeolite-like metal-organic framework (ZIF-67) was developed for highly sensitive and stable determination of folic acid (FA). The ZIF-67/AgNWs nanocomposite was prepared by a one-step reaction via a template method and drop-coated onto the surface of a screen-printed carbon electrode (SPCE) to form a ZIF-67/AgNWs@SPCE electrochemical sensing platform. The electrochemical square wave voltammetry (SWV) curve for this sensing platform was measured in an electrolyte solution containing FA under the optimum experimental conditions. The redox peak current of FA () increased with increases in the FA concentration (). There was a linear relationship between and in the range of 0.1 μM to 10 μM, and the determination limit was 30 nM. The ZIF-67/AgNWs@SPCE was used as an electrochemical sensor for FA which maintained a good stability over 7 days and showed good determination performance in real samples with a high recovery rate (100.9-102.1%, = 6).

采用银纳米线（AgNWs）掺杂沸石状金属有机骨架（ZIF-67）的电化学传感器，用于高度灵敏和稳定地测定叶酸（FA）。ZIF-67/AgNWs 纳米复合材料通过模板法的一步反应制备，并滴涂到丝网印刷碳电极（SPCE）的表面上，形成 ZIF-67/AgNWs@SPCE 电化学传感平台。在含有 FA 的最佳实验条件下，在电解质溶液中测量此传感平台的电化学方波伏安法（SWV）曲线。FA 的氧化还原峰电流（）随着 FA 浓度（）的增加而增加。在 0.1 μM 至 10 μM 的范围内，与呈线性关系，测定下限为 30 nM。ZIF-67/AgNWs@SPCE 被用作 FA 的电化学传感器，在 7 天内保持良好的稳定性，并在实际样品中表现出良好的测定性能，回收率高（100.9-102.1%，n = 6）。