Youssoufenes A2 和 A3，来自海洋来源菌株 Δ 突变体的抗生素二聚肉桂酰脂类化合物。
Youssoufenes A2 and A3, Antibiotic Dimeric Cinnamoyl Lipids from the Δ Mutant of a Marine-Derived Strain.
机构信息
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
出版信息
Mar Drugs. 2022 Jun 15;20(6):394. doi: 10.3390/md20060394.
Two new dimeric cinnamoyl lipids (CL) featuring with an unusual dearomatic carbon-bridge, named youssoufenes A2 () and A3 (), were isolated from the Δ mutant strain of marine-derived OUC6819. Structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses, and their absolute configurations were determined by combination of the long-range NOE-based H-H distance measurements and ECD calculations. Compounds and exhibited moderate growth inhibition against multi-drug-resistant CCARM 5172 with an MIC value of 22.2 μM.
两个新的二聚肉桂酰基脂（CL）具有不寻常的去芳碳桥，命名为youssoufenes A2()和 A3()，从海洋来源的Δ突变株 OUC6819 中分离得到。根据广泛的 MS 和 NMR 光谱分析，分离得到的化合物的结构得到了阐明，它们的绝对构型通过远程基于 NOE 的 H-H 距离测量和 ECD 计算的组合来确定。化合物和对多药耐药 CCARM 5172 表现出中等的生长抑制活性，MIC 值为 22.2 μM。
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