Pal Ajay Kumar, Sharma Prateek, Zia Alishan, Siwan Deepali, Nandave Dipali, Nandave Mukesh, Gautam Rupesh K
Department of Pharmacology, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
Department of Dravyaguna, Karmavir V. T. Randhir Ayurved College, Boradi 425428, India.
Pathophysiology. 2022 May 27;29(2):200-222. doi: 10.3390/pathophysiology29020017.
Cancer cells undergo transient EMT and MET phenomena or vice versa, along with the parallel interplay of various markers, often correlated as the determining factor in decoding metabolic profiling of breast cancers. Moreover, various cancer signaling pathways and metabolic changes occurring in breast cancer cells modulate the expression of such markers to varying extents. The existing research completed so far considers the expression of such markers as determinants regulating the invasiveness and survival of breast cancer cells. Therefore, this manuscript is crosstalk among the expression levels of such markers and their correlation in regulating the aggressiveness and invasiveness of breast cancer. We also attempted to cover the possible EMT-based metabolic targets to retard migration and invasion of breast cancer.
癌细胞会经历短暂的上皮-间质转化（EMT）和间质-上皮转化（MET）现象，反之亦然，同时伴随着各种标志物的平行相互作用，这些标志物通常相互关联，是解读乳腺癌代谢谱的决定性因素。此外，乳腺癌细胞中发生的各种癌症信号通路和代谢变化在不同程度上调节这些标志物的表达。迄今为止完成的现有研究将这些标志物的表达视为调节乳腺癌细胞侵袭性和存活率的决定因素。因此，本手稿探讨了这些标志物的表达水平之间的相互作用及其在调节乳腺癌侵袭性和转移性方面的相关性。我们还试图涵盖基于EMT的可能代谢靶点，以延缓乳腺癌的迁移和侵袭。
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