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鉴定和临床验证 NUSAP1 作为卵巢癌的一种新的预后生物标志物。

Identification and clinical validation of NUSAP1 as a novel prognostic biomarker in ovarian cancer.

机构信息

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Liaoning, 110004, China.

Key Laboratory of Maternal-Fetal Medicine of Liaoning Province, Key Laboratory of Obstetrics and Gynecology of Higher Education of Liaoning Province, Liaoning, China.

出版信息

BMC Cancer. 2022 Jun 23;22(1):690. doi: 10.1186/s12885-022-09753-4.

DOI:10.1186/s12885-022-09753-4
PMID:35739489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9229913/
Abstract

BACKGROUND

Nucleolar and spindle-associated protein 1 (NUSAP1) was shown to be involved in cell cycle regulation in cancer. However, its prognostic value and underlying mechanism in ovarian cancer remain unclear.

METHODS

Oncomine, TCGA, CCLE, and UALCAN databases were used to analyze the expression level of NUSAP1 in ovarian cancer. The Kaplan-Meier plotter database was used to evaluate its prognostic value. The results from these analyses were further validated using immunohistochemical assay. The potential molecular mechanism of NUSAP1 in ovarian cancer was assessed with respect to homologous recombination repair, mismatch repair, and immunology using different databases.

RESULTS

Database analyses and experimental results demonstrated that NUSAP1 was highly expressed in ovarian cancer, its levels being correlated with the FIGO stage. High NUSAP1 expression was an independent risk factor affecting the prognosis of patients with epithelial ovarian cancer. Moreover, NUSAP1 was associated with cell cycle, DNA replication, homologous recombination, and p53 signaling pathway. A positive correlation was identified between the expression of NUSAP1 and BRCA1/2 in ovarian cancer. In addition, NUSAP1 was associated with the expression of DNA mismatch repair genes and immune cell infiltration.

CONCLUSIONS

NUSAP1 may be a valuable prognostic marker, as well as a novel biomarker for evaluating the response to immunotherapy of patients with ovarian cancer.

摘要

背景

核仁纺锤体相关蛋白 1（NUSAP1）被证明参与癌症中的细胞周期调控。然而，其在卵巢癌中的预后价值和潜在机制尚不清楚。

方法

使用 Oncomine、TCGA、CCLE 和 UALCAN 数据库分析卵巢癌中 NUSAP1 的表达水平。使用 Kaplan-Meier plotter 数据库评估其预后价值。使用免疫组织化学检测进一步验证这些分析结果。使用不同的数据库评估 NUSAP1 在卵巢癌中同源重组修复、错配修复和免疫学方面的潜在分子机制。

结果

数据库分析和实验结果表明，NUSAP1 在卵巢癌中高表达，其水平与 FIGO 分期相关。高 NUSAP1 表达是影响上皮性卵巢癌患者预后的独立危险因素。此外，NUSAP1 与细胞周期、DNA 复制、同源重组和 p53 信号通路有关。在卵巢癌中，NUSAP1 的表达与 BRCA1/2 呈正相关。此外，NUSAP1 与 DNA 错配修复基因的表达和免疫细胞浸润有关。

结论

NUSAP1 可能是一个有价值的预后标志物，也是评估卵巢癌患者免疫治疗反应的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/62d2667b0676/12885_2022_9753_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/bdaf988b2ead/12885_2022_9753_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/512657c27944/12885_2022_9753_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/0a351c24ec27/12885_2022_9753_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/3c9758cbb81e/12885_2022_9753_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/787031ad6ce6/12885_2022_9753_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/62d2667b0676/12885_2022_9753_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/bdaf988b2ead/12885_2022_9753_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/512657c27944/12885_2022_9753_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/0a351c24ec27/12885_2022_9753_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/3c9758cbb81e/12885_2022_9753_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/787031ad6ce6/12885_2022_9753_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df51/9229913/62d2667b0676/12885_2022_9753_Fig6_HTML.jpg

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