Uzal Francisco A, Giannitti Federico, Asin Javier
California Animal Health and Food Safety, University of California-Davis, San Bernardino, CA 92408, USA.
Plataforma de Investigación en Salud Animal, Instituto de Investigación Agropecuaria, Estación Experimental La Estanzuela, Colonia 70000, Uruguay.
Animals (Basel). 2022 Jun 20;12(12):1590. doi: 10.3390/ani12121590.
Yellow lamb disease is an infrequent disease in sheep for which there is scant literature, and that has been reported in the US, Australia, New Zealand, South Africa and Europe, although anecdotal evidence indicates that it may have also been diagnosed in South America. The disease is produced by some strains of type A that produce unusually high levels of alpha- toxin. Because type A is ubiquitous and is found in the intestine of most clinically healthy sheep, diagnosis of yellow lamb disease is challenging and requires quantitating the amount of this microorganism present in feces and/or intestinal content. Clinically, yellow lamb disease is characterized by depression, anemia, icterus and hemoglobinuria. Occasionally, sudden death may occur. Gross findings include generalized icterus, red urine in the bladder, enlarged, pale, and friable spleen, enlarged liver with an acinar pattern, and dark, swollen kidneys. Microscopically, yellow lamb disease is characterized by centrilobular necrosis of the liver, hemoglobinuria-associated acute tubular injury, splenic congestion, pulmonary congestion and edema. Although there are no vaccines specifically designed to prevent yellow lamb disease, several vaccines against the different types of may afford at least some level of protection against yellow lamb disease.
黄羔病是绵羊中一种罕见的疾病，相关文献稀少，在美国、澳大利亚、新西兰、南非和欧洲均有报道，尽管有传闻证据表明南美洲也可能诊断出该病。该病由某些产生异常高水平α毒素的A型菌株引起。由于A型普遍存在于大多数临床健康绵羊的肠道中，黄羔病的诊断具有挑战性，需要对粪便和/或肠道内容物中这种微生物的数量进行定量。临床上，黄羔病的特征为抑郁、贫血、黄疸和血红蛋白尿。偶尔可能会突然死亡。大体检查结果包括全身黄疸、膀胱内红色尿液、脾脏肿大、苍白且易碎、肝脏肿大呈腺泡状以及肾脏暗黑、肿胀。显微镜下，黄羔病的特征为肝小叶中心坏死、与血红蛋白尿相关的急性肾小管损伤、脾充血、肺充血和水肿。虽然没有专门设计用于预防黄羔病的疫苗，但几种针对不同类型（此处原文不完整）的疫苗可能至少提供一定程度的针对黄羔病的保护。
