Tuca Alexandru-Cristian, Bernardelli de Mattos Ives, Funk Martin, Winter Raimund, Palackic Alen, Groeber-Becker Florian, Kruse Daniel, Kukla Fabian, Lemarchand Thomas, Kamolz Lars-Peter
Department of Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University of Graz, 8036 Graz, Austria.
Department Tissue Engineering & Regenerative Medicine (TERM), University Hospital Würzburg, 97080 Würzburg, Germany.
Biomedicines. 2022 May 31;10(6):1286. doi: 10.3390/biomedicines10061286.
A balanced and moist wound environment and surface increases the effect of various growth factors, cytokines, and chemokines, stimulating cell growth and wound healing. Considering this fact, we tested in vitro and in vivo water evaporation rates from the cellulose dressing epicite when combined with different secondary dressings as well as the resulting wound healing efficacy in a porcine donor site model. The aim of this study was to evaluate how the different rates of water evaporation affected wound healing efficacy. To this end, epicite primary dressing, in combination with different secondary dressing materials (cotton gauze, JELONET, AQUACEL Extra ™, and OPSITE Flexifix), was placed on 3 × 3 cm-sized dermatome wounds with a depth of 1.2 mm on the flanks of domestic pigs. The healing process was analyzed histologically and quantified by morphometry. High water evaporation rates by using the correct secondary dressing, such as cotton gauze, favored a better re-epithelialization in comparison with the low water evaporation resulting from an occlusive secondary dressing, which favored the formation of a new and intact dermal tissue that nearly fully replaced all the dermis that was removed during wounding. This newly available evidence may be of great benefit to clinical wound management.
平衡且湿润的伤口环境及表面可增强各种生长因子、细胞因子和趋化因子的作用，刺激细胞生长和伤口愈合。鉴于这一事实，我们在体外和体内测试了纤维素敷料Epicite与不同二级敷料联合使用时的水分蒸发速率，以及在猪供皮区模型中由此产生的伤口愈合效果。本研究的目的是评估不同的水分蒸发速率如何影响伤口愈合效果。为此，将Epicite初级敷料与不同的二级敷料材料（棉纱布、JELONET、AQUACEL Extra™和OPSITE Flexifix）相结合，放置在家猪侧腹上3×3厘米大小、深度为1.2毫米的断层皮片伤口上。通过组织学分析愈合过程，并通过形态测量进行量化。与封闭性二级敷料导致的低水分蒸发相比，使用正确的二级敷料（如棉纱布）实现的高水分蒸发速率有利于更好的上皮再形成，封闭性二级敷料导致的低水分蒸发有利于形成新的完整真皮组织，几乎完全替代了受伤期间去除的所有真皮。这一新获得的证据可能对临床伤口管理大有裨益。
