人淋巴细胞中粪五烯-12诱导的染色体畸变的剂量-反应关系。
Dose-response relationship for chromosome aberrations induced by fecapentaene-12 in human lymphocytes.
作者信息
Schmid E, Bauchinger M, Braselmann H, Pfaendler H R, Göggelmann W
出版信息
Mutat Res. 1987 May;191(1):5-7. doi: 10.1016/0165-7992(87)90161-8.
PMID:3574340
Abstract
Chromosome analyses were carried out in human lymphocytes exposed to a synthetic racemic all-trans fecapentaene-12 at 2-24 microM. A dose-dependent increase of the incidences of chromatid-type changes with distinct saturation at higher doses could be observed. The results reveal for the first time that fec-12 is a potent direct-acting mutagen in human lymphocytes.
摘要
对暴露于2至24微摩尔合成外消旋全反式粪五烯-12的人淋巴细胞进行了染色体分析。可以观察到染色单体型变化发生率呈剂量依赖性增加，且在较高剂量时有明显的饱和现象。结果首次揭示粪五烯-12是一种在人淋巴细胞中有强效直接作用的诱变剂。
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