Kwon Mi Jung, Han Kyeong Min, Kim Ji Hee, Kim Joo-Hee, Kim Min-Jeong, Kim Nan Young, Choi Hyo Geun, Kang Ho Suk
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
J Pers Med. 2024 Feb 21;14(3):229. doi: 10.3390/jpm14030229.
Given the global significance of gout and gastric cancer (GC) as major health problems with interrelated impacts, we examined the development of GC in Korean patients with gout. We conducted a nested case-control study using data from 10,174 GC patients and 40,696 control patients from the Korean National Health Insurance Service-National Sample Cohort database. Propensity score matching (1:4) with propensity score overlap-weighted adjustment was used to reduce selection bias and estimate the odds ratio (OR) and 95% confidence intervals (CIs) for the association between gout and GC. An adjusted OR for GC was not significantly higher in patients with gout than in control patients (1.02; 95% CI, 0.93-1.12; = 0.652). Additionally, no association between gout and GC was observed in subgroup analyses such as sex, age, level of income, region of residence, or Charlson Comorbidity Index score. In conclusion, these results suggest that gout is not a significant independent risk factor for GC among the Korean population. Additional investigation is required to establish a causal association between gout and GC, and to generalize these results to general populations.
鉴于痛风和胃癌（GC）作为具有相互关联影响的主要健康问题具有全球重要性，我们研究了韩国痛风患者中胃癌的发病情况。我们使用来自韩国国民健康保险服务 - 全国样本队列数据库的10174例胃癌患者和40696例对照患者的数据进行了一项巢式病例对照研究。采用倾向评分匹配（1:4）和倾向评分重叠加权调整来减少选择偏倚，并估计痛风与胃癌关联的比值比（OR）和95%置信区间（CI）。痛风患者发生胃癌的校正OR并不显著高于对照患者（1.02；95%CI，0.93 - 1.12；P = 0.652）。此外，在性别、年龄、收入水平、居住地区或查尔森合并症指数评分等亚组分析中，未观察到痛风与胃癌之间存在关联。总之，这些结果表明痛风在韩国人群中不是胃癌的显著独立危险因素。需要进一步研究以确定痛风与胃癌之间的因果关系，并将这些结果推广至一般人群。
