• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TRIM24表达作为头颈部鳞状细胞癌预后和肿瘤复发的独立生物标志物

TRIM24 Expression as an Independent Biomarker for Prognosis and Tumor Recurrence in HNSCC.

作者信息

Klapper Luise, Idel Christian, Kuppler Patrick, Jagomast Tobias, von Bernuth Amelie, Bruchhage Karl-Ludwig, Rades Dirk, Offermann Anne, Kirfel Jutta, Perner Sven, Ribbat-Idel Julika

机构信息

Institute of Pathology, University of Luebeck, University Hospital Schleswig-Holstein, Campus Luebeck, 23538 Luebeck, Germany.

Department of Otorhinolaryngology, University of Luebeck, 23538 Luebeck, Germany.

出版信息

J Pers Med. 2022 Jun 17;12(6):991. doi: 10.3390/jpm12060991.

DOI:10.3390/jpm12060991
PMID:35743773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9225579/
Abstract

BACKGROUND

Head and neck squamous cell carcinomas (HNSCCs) are among the most common cancers in humans worldwide and have a rather poor prognosis. TRIM24 has various intracellular functions and was identified in other cancer entities as a poor prognostic factor for patients.

METHODS

The expression of TRIM24 was evaluated by using immunohistochemistry. We used a large and representative cohort of 341 HNSCC patients. Data derived from immunohistochemistry evaluation was correlated with clinicopathological data from HNSCC patients.

RESULTS

The TRIM24 expression in HNSCC primary tumors is negatively correlated with the p16 status of the tumor tissues. Primary tumors of patients who developed a local recurrence were significantly more often positive for TRIM24. Kaplan-Meier analyses and Cox regression showed that patients with TRIM24 expressing tumors have significantly worse overall survival and progression-free survival and that TRIM24 expression is independent of other established risk factors.

CONCLUSIONS

TRIM24 might be a new prognostic biomarker for the survival prognosis and early detection of local recurrences in HNSCC patients. It could be used for risk stratification of HNSCC patients and to identify those patients who are more prone to develop a local recurrence and therefore could profit from more frequent follow-up examinations.

摘要

背景

头颈部鳞状细胞癌（HNSCC）是全球人类中最常见的癌症之一，预后相当差。TRIM24具有多种细胞内功能，在其他癌症实体中被确定为患者的不良预后因素。

方法

采用免疫组织化学法评估TRIM24的表达。我们使用了一个由341例HNSCC患者组成的具有代表性的大样本队列。免疫组织化学评估得出的数据与HNSCC患者的临床病理数据相关。

结果

HNSCC原发肿瘤中TRIM24的表达与肿瘤组织的p16状态呈负相关。发生局部复发的患者的原发肿瘤TRIM24阳性率显著更高。Kaplan-Meier分析和Cox回归显示，TRIM24表达阳性的肿瘤患者的总生存期和无进展生存期明显更差，且TRIM24的表达独立于其他已确定的风险因素。

结论

TRIM24可能是HNSCC患者生存预后和局部复发早期检测的一种新的预后生物标志物。它可用于HNSCC患者的风险分层，并识别那些更易发生局部复发、因此可能从更频繁的随访检查中获益的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/e14ee7766bda/jpm-12-00991-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/6924cc0518e1/jpm-12-00991-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/8778528f6d6a/jpm-12-00991-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/bb605ebe9d9b/jpm-12-00991-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/e58edba0b45b/jpm-12-00991-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/193579bb2cb5/jpm-12-00991-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/774a2a5d57d9/jpm-12-00991-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/e14ee7766bda/jpm-12-00991-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/6924cc0518e1/jpm-12-00991-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/8778528f6d6a/jpm-12-00991-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/bb605ebe9d9b/jpm-12-00991-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/e58edba0b45b/jpm-12-00991-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/193579bb2cb5/jpm-12-00991-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/774a2a5d57d9/jpm-12-00991-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18c4/9225579/e14ee7766bda/jpm-12-00991-g007.jpg

相似文献

1
TRIM24 Expression as an Independent Biomarker for Prognosis and Tumor Recurrence in HNSCC.TRIM24表达作为头颈部鳞状细胞癌预后和肿瘤复发的独立生物标志物
J Pers Med. 2022 Jun 17;12(6):991. doi: 10.3390/jpm12060991.
2
TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes.TRIM24 过表达在局部晚期头颈部鳞状细胞癌中很常见，并且与侵袭性恶性表型相关。
PLoS One. 2013 May 22;8(5):e63887. doi: 10.1371/journal.pone.0063887. Print 2013.
3
NR2F6 as a Prognostic Biomarker in HNSCC.NR2F6 作为头颈部鳞状细胞癌的预后生物标志物。
Int J Mol Sci. 2020 Aug 1;21(15):5527. doi: 10.3390/ijms21155527.
4
TRIM24 as an independent prognostic biomarker for prostate cancer.TRIM24 作为前列腺癌的独立预后生物标志物。
Urol Oncol. 2019 Sep;37(9):576.e1-576.e10. doi: 10.1016/j.urolonc.2019.05.006. Epub 2019 Jun 7.
5
Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis.葡萄糖转运蛋白4通过TRIM24-DDX58轴促进头颈部鳞状细胞癌转移。
J Hematol Oncol. 2017 Jan 7;10(1):11. doi: 10.1186/s13045-016-0372-0.
6
TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma.转运蛋白18 kDa（TSPO）是一种与头颈部鳞状细胞癌中的细胞呼吸和p16相关的潜在独立预后因素。
Front Oncol. 2023 Dec 14;13:1298333. doi: 10.3389/fonc.2023.1298333. eCollection 2023.
7
Elevated LSD1 and SNAIL Expression Indicate Poor Prognosis in Hypopharynx Carcinoma.LSD1 和 SNAIL 表达升高提示下咽癌预后不良。
Int J Mol Sci. 2022 May 3;23(9):5075. doi: 10.3390/ijms23095075.
8
Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma.TRIM24 过表达促进头颈部鳞状细胞癌的增殖和葡萄糖代谢。
Biomed Res Int. 2018 May 10;2018:6142843. doi: 10.1155/2018/6142843. eCollection 2018.
9
MAGE-A11 Expression Predicts Patient Prognosis in Head and Neck Squamous Cell Carcinoma.MAGE - A11表达可预测头颈部鳞状细胞癌患者的预后。
Cancer Manag Res. 2020 Feb 26;12:1427-1435. doi: 10.2147/CMAR.S237867. eCollection 2020.
10
Prognostic relevance of tripartite motif containing 24 expression in colorectal cancer.含三联基序蛋白24在结直肠癌中的表达与预后的相关性
Pathol Res Pract. 2017 Oct;213(10):1271-1275. doi: 10.1016/j.prp.2017.08.008. Epub 2017 Aug 25.

引用本文的文献

1
TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes.TRIM24调节心肌细胞中的染色质重塑和钙动力学。
Cell Commun Signal. 2025 Jul 1;23(1):312. doi: 10.1186/s12964-025-02323-8.
2
The tripartite motif-containing 24 is a multifunctional player in human cancer.含三联基序的蛋白24在人类癌症中发挥着多功能作用。
Cell Biosci. 2024 Aug 19;14(1):103. doi: 10.1186/s13578-024-01289-3.
3
Identifying Predictive Biomarkers for Head and Neck Squamous Cell Carcinoma Response.确定头颈部鳞状细胞癌反应的预测生物标志物。

本文引用的文献

1
Tumor suppressor p53 cross-talks with TRIM family proteins.肿瘤抑制因子p53与TRIM家族蛋白相互作用。
Genes Dis. 2020 Jul 16;8(4):463-474. doi: 10.1016/j.gendis.2020.07.003. eCollection 2021 Jul.
2
Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma.不同诊断性程序性死亡受体配体1（PD-L1）克隆在头颈部鳞状细胞癌中的表现
Front Med (Lausanne). 2021 Apr 27;8:640515. doi: 10.3389/fmed.2021.640515. eCollection 2021.
3
Immunologic "Cold" Squamous Cell Carcinomas of the Head and Neck Are Associated With an Unfavorable Prognosis.
Cancers (Basel). 2023 Nov 27;15(23):5597. doi: 10.3390/cancers15235597.
4
The Role of TRIM24 in Allergic Rhinitis.TRIM24在变应性鼻炎中的作用
Allergy Asthma Immunol Res. 2023 Sep;15(5):543-544. doi: 10.4168/aair.2023.15.5.543.
5
TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC.TRIM21 表达作为 HNSCC 无进展生存期的预后生物标志物。
Int J Mol Sci. 2023 Mar 7;24(6):5140. doi: 10.3390/ijms24065140.
6
Bromodomain (BrD) Family Members as Regulators of Cancer Stemness-A Comprehensive Review.溴结构域家族成员作为癌症干性的调控因子——全面综述。
Int J Mol Sci. 2023 Jan 4;24(2):995. doi: 10.3390/ijms24020995.
7
Identification of bromodomain-containing proteins prognostic value and expression significance based on a genomic landscape analysis of ovarian serous cystadenocarcinoma.基于卵巢浆液性囊腺癌基因组格局分析鉴定含溴结构域蛋白的预后价值及表达意义
Front Oncol. 2022 Oct 5;12:1021558. doi: 10.3389/fonc.2022.1021558. eCollection 2022.
8
Antiproliferative Copper(II) Complexes Bearing Mixed Chelating Ligands: Structural Characterization, ROS Scavenging, In Silico Studies, and Anti-Melanoma Activity.含混合螯合配体的抗增殖铜（II）配合物：结构表征、活性氧清除、计算机模拟研究及抗黑色素瘤活性
Pharmaceutics. 2022 Aug 14;14(8):1692. doi: 10.3390/pharmaceutics14081692.
头颈部免疫性“冷”鳞状细胞癌与不良预后相关。
Front Med (Lausanne). 2021 Jan 27;8:622330. doi: 10.3389/fmed.2021.622330. eCollection 2021.
4
Head and neck squamous cell carcinoma.头颈部鳞状细胞癌
Nat Rev Dis Primers. 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3.
5
CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.CDK7 是上皮性卵巢癌的一个可靠的预后因素和新的治疗靶点。
Gynecol Oncol. 2020 Jan;156(1):211-221. doi: 10.1016/j.ygyno.2019.11.004. Epub 2019 Nov 24.
6
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).癌症免疫治疗学会关于免疫治疗头颈部鳞状细胞癌（HNSCC）的共识声明。
J Immunother Cancer. 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5.
7
TRIM24 as an independent prognostic biomarker for prostate cancer.TRIM24 作为前列腺癌的独立预后生物标志物。
Urol Oncol. 2019 Sep;37(9):576.e1-576.e10. doi: 10.1016/j.urolonc.2019.05.006. Epub 2019 Jun 7.
8
Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy.头颈部鳞状细胞癌免疫景观的异质性及其对免疫治疗的影响。
Front Cell Dev Biol. 2019 Apr 9;7:52. doi: 10.3389/fcell.2019.00052. eCollection 2019.
9
Epidemiology of Head and Neck Squamous Cell Carcinomas: Impact on Staging and Prevention Strategies.头颈部鳞状细胞癌的流行病学：对分期和预防策略的影响。
Curr Treat Options Oncol. 2019 Apr 22;20(5):43. doi: 10.1007/s11864-019-0650-5.
10
Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma.原发放疗对比手术治疗局部晚期老年口咽鳞癌患者的疗效。
Oral Oncol. 2019 Jan;88:18-26. doi: 10.1016/j.oraloncology.2018.11.004. Epub 2018 Nov 16.