Zemestani Maryam, Rafraf Maryam, Asghari-Jafarabadi Mohammad
Students' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition. 2016 Jan;32(1):66-72. doi: 10.1016/j.nut.2015.07.011. Epub 2015 Aug 14.
Oxidative stress is a major factor in the pathogenesis of diabetes complications. The objectives were to investigate the effects of chamomile tea consumption on glycemic control and antioxidant status in subjects with type 2 diabetes mellitus (T2 DM).
This single-blind randomized controlled clinical trial was conducted on 64 subjects with T2 DM (males and females) ages 30 to 60 y. The intervention group (n = 32) consumed chamomile tea (3 g/150 mL hot water) 3 times per day immediately after meals for 8 wk. The control group (n = 32) followed a water regimen for same intervention period. Fasting blood samples, anthropometric measurements, and 3-d, 24-h dietary recalls were collected at the baseline and at the end of the trial. Data were analyzed by independent t test, paired t test, and analysis of covariance.
Chamomile tea significantly decreased concentration of glycosylated hemoglobin, serum insulin levels, homeostatic model assessment for insulin resistance, and serum malondialdehyde, compared with control group (all P < 0.05). Total antioxidant capacity, superoxide dismutase, glutathione peroxidase, and catalase activities were significantly increased by 6.81%, 26.16 %, 36.71 % and 45.06% respectively in chamomile group compared with these variables in control group at the end of the intervention (all P < 0.05).
Short term intake of chamomile tea has beneficial effects on glycemic control and antioxidant status in patients with T2 DM. A larger sample population and a longer intervention period may be required to show significant clinical improvements.
氧化应激是糖尿病并发症发病机制中的一个主要因素。本研究旨在探讨饮用洋甘菊茶对2型糖尿病（T2 DM）患者血糖控制和抗氧化状态的影响。
本单盲随机对照临床试验纳入了64名年龄在30至60岁之间的T2 DM患者（男女皆有）。干预组（n = 32）每天餐后立即饮用洋甘菊茶（3 g/150 mL热水）3次，持续8周。对照组（n = 32）在相同干预期间饮用白水。在基线和试验结束时采集空腹血样、人体测量数据以及3天、24小时饮食回忆。数据采用独立t检验、配对t检验和协方差分析进行分析。
与对照组相比，洋甘菊茶显著降低了糖化血红蛋白浓度、血清胰岛素水平、胰岛素抵抗稳态模型评估以及血清丙二醛水平（所有P < 0.05）。干预结束时，与对照组相比，洋甘菊组的总抗氧化能力、超氧化物歧化酶、谷胱甘肽过氧化物酶和过氧化氢酶活性分别显著提高了6.81%、26.16%、36.71%和45.06%（所有P < 0.05）。
短期饮用洋甘菊茶对T2 DM患者的血糖控制和抗氧化状态具有有益作用。可能需要更大的样本量和更长的干预期才能显示出显著的临床改善。
