Hamame Afaf, Davoust Bernard, Cherak Zineb, Rolain Jean-Marc, Diene Seydina M
Faculté de Pharmacie, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Aix Marseille University, 19-21 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.
IHU-Méditerranée Infection, 19-21 Boulevard Jean Moulin, CEDEX 05, 13385 Marseille, France.
Pathogens. 2022 Jun 17;11(6):698. doi: 10.3390/pathogens11060698.
: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through genes in pets. The current study also highlights the health risks of the transmission of colistin resistance between pets and humans. : We conducted a systematic review on -positive bacteria in pets and studies reporting their zoonotic transmission to humans. Bibliographic research queries were performed on the following databases: Google Scholar, PubMed, Scopus, Microsoft Academic, and Web of Science. Articles of interest were selected using the PRISMA guideline principles. : The analyzed articles from the investigated databases described the presence of gene variants in pets including , , , , , , and . Among these articles, four studies reported potential zoonotic transmission of genes between pets and humans. The epidemiological analysis revealed that dogs and cats can be colonized by genes that are beginning to spread in different countries worldwide. Overall, reported articles on this subject highlight the high risk of zoonotic transmission of colistin resistance genes between pets and their owners. : This review demonstrated the spread of genes in pets and their transmission to humans, indicating the need for further measures to control this significant threat to public health. Therefore, we suggest here some strategies against this threat such as avoiding zoonotic transmission.
宠物，尤其是猫和狗，具有很大的人畜共患病传播潜力，会导致重大健康问题。本系统评价的目的是介绍宠物中通过基因产生的黏菌素耐药性的最新进展。本研究还强调了宠物与人类之间黏菌素耐药性传播的健康风险。：我们对宠物中的阳性细菌以及报告它们向人类进行人畜共患病传播的研究进行了系统评价。在以下数据库中进行了文献检索查询：谷歌学术、PubMed、Scopus、微软学术和科学网。使用PRISMA指南原则选择感兴趣的文章。：从所调查数据库中分析的文章描述了宠物中基因变体的存在，包括、、、、、、和。在这些文章中，四项研究报告了基因在宠物与人类之间可能的人畜共患病传播。流行病学分析表明，狗和猫可能被在全球不同国家开始传播的基因定殖。总体而言，关于该主题的已报道文章强调了黏菌素耐药基因在宠物与其主人之间进行人畜共患病传播的高风险。：本评价证明了基因在宠物中的传播及其向人类的传播，表明需要采取进一步措施来控制这一对公共卫生的重大威胁。因此，我们在此提出一些应对这一威胁的策略，如避免人畜共患病传播。
