• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

支持医学对策研发的自然史。

Natural History of to Support Medical Countermeasure Development.

作者信息

Carbonnelle Caroline, Moroso Marie, Pannetier Delphine, Godard Sabine, Mély Stéphane, Thomas Damien, Duthey Aurélie, Jourjon Ophélie, Lacroix Orianne, Labrosse Béatrice, Raoul Hervé, Osman Karen L, Salguero Francisco J, Hall Yper, Sabourin Carol L, Merchlinsky Michael J, Long James P, Parish Lindsay A, Wolfe Daniel N

机构信息

Inserm, Laboratoire P4 Jean Mérieux, 69007 Lyon, France.

Evotec Id, 69007 Lyon, France.

出版信息

Vaccines (Basel). 2022 Jun 16;10(6):963. doi: 10.3390/vaccines10060963.

DOI:10.3390/vaccines10060963
PMID:35746571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9228702/
Abstract

(SUDV) is one of four members of the genus known to cause Ebola Virus Disease (EVD) in humans, which is characterized by hemorrhagic fever and a high case fatality rate. While licensed therapeutics and vaccines are available in limited number to treat infections of Zaire ebolavirus, there are currently no effective licensed vaccines or therapeutics for SUDV. A well-characterized animal model of this disease is needed for the further development and testing of vaccines and therapeutics. In this study, twelve cynomolgus macaques () were challenged intramuscularly with 1000 PFUs of SUDV and were followed under continuous telemetric surveillance. Clinical observations, body weights, temperature, viremia, hematology, clinical chemistry, and coagulation were analyzed at timepoints throughout the study. Death from SUDV disease occurred between five and ten days after challenge at the point that each animal met the criteria for euthanasia. All animals were observed to exhibit clinical signs and lesions similar to those observed in human cases which included: viremia, fever, dehydration, reduced physical activity, macular skin rash, systemic inflammation, coagulopathy, lymphoid depletion, renal tubular necrosis, hepatocellular degeneration and necrosis. The results from this study will facilitate the future preclinical development and evaluation of vaccines and therapeutics for SUDV.

摘要

苏丹埃博拉病毒（SUDV）是已知能导致人类埃博拉病毒病（EVD）的四种病毒属成员之一，该病以出血热和高病死率为特征。虽然有数量有限的已获许可的治疗药物和疫苗可用于治疗扎伊尔埃博拉病毒感染，但目前尚无针对苏丹埃博拉病毒的有效已获许可的疫苗或治疗药物。需要一种特征明确的该疾病动物模型来进一步开发和测试疫苗及治疗药物。在本研究中，12只食蟹猴通过肌肉注射1000个噬斑形成单位（PFU）的苏丹埃博拉病毒进行攻毒，并在持续遥测监测下进行跟踪。在整个研究过程中的各个时间点对临床观察、体重、体温、病毒血症、血液学、临床化学和凝血情况进行了分析。苏丹埃博拉病毒病导致的死亡发生在攻毒后5至10天，此时每只动物均符合安乐死标准。观察到所有动物均表现出与人类病例中观察到的类似临床症状和病变，包括：病毒血症、发热、脱水、身体活动减少、斑丘疹、全身炎症、凝血病、淋巴细胞耗竭、肾小管坏死、肝细胞变性和坏死。本研究结果将有助于未来针对苏丹埃博拉病毒的疫苗和治疗药物的临床前开发和评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/3bb2f2f8a646/vaccines-10-00963-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/6e90e3f1a88c/vaccines-10-00963-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/a0c462526a50/vaccines-10-00963-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/0f61a99ad761/vaccines-10-00963-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/b938211acd31/vaccines-10-00963-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/88cf1db0e5eb/vaccines-10-00963-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/c664e151d275/vaccines-10-00963-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/e23b912fe80f/vaccines-10-00963-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/5cf23d58098e/vaccines-10-00963-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/42d910b96f08/vaccines-10-00963-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/61ae57d1a40d/vaccines-10-00963-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/3bb2f2f8a646/vaccines-10-00963-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/6e90e3f1a88c/vaccines-10-00963-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/a0c462526a50/vaccines-10-00963-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/0f61a99ad761/vaccines-10-00963-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/b938211acd31/vaccines-10-00963-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/88cf1db0e5eb/vaccines-10-00963-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/c664e151d275/vaccines-10-00963-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/e23b912fe80f/vaccines-10-00963-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/5cf23d58098e/vaccines-10-00963-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/42d910b96f08/vaccines-10-00963-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/61ae57d1a40d/vaccines-10-00963-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc4/9228702/3bb2f2f8a646/vaccines-10-00963-g011.jpg

相似文献

1
Natural History of to Support Medical Countermeasure Development.支持医学对策研发的自然史。
Vaccines (Basel). 2022 Jun 16;10(6):963. doi: 10.3390/vaccines10060963.
2
Natural history of infection in rhesus and cynomolgus macaques.恒河猴和食蟹猴感染的自然史。
Emerg Microbes Infect. 2022 Dec;11(1):1635-1646. doi: 10.1080/22221751.2022.2086072.
3
Delayed treatment of cynomolgus macaques with a FVM04/CA45 monoclonal antibody cocktail provides complete protection against lethal Sudan virus infection.延迟使用 FVM04/CA45 单克隆抗体鸡尾酒治疗食蟹猴可提供针对致死性苏丹病毒感染的完全保护。
J Virol. 2024 Aug 20;98(8):e0124223. doi: 10.1128/jvi.01242-23. Epub 2024 Jul 16.
4
Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection.耐热两价丝状病毒疫苗可预防严重和致命的苏丹埃博拉病毒和马尔堡病毒感染。
Vaccine. 2024 Jan 25;42(3):598-607. doi: 10.1016/j.vaccine.2023.12.053. Epub 2023 Dec 28.
5
Distinct Immunogenicity and Efficacy of Poxvirus-Based Vaccine Candidates against Ebola Virus Expressing GP and VP40 Proteins.基于痘病毒的埃博拉病毒表达 GP 和 VP40 蛋白疫苗候选物的免疫原性和疗效的差异。
J Virol. 2018 May 14;92(11). doi: 10.1128/JVI.00363-18. Print 2018 Jun 1.
6
Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development.开发一种特征明确的用于支持产品研发的苏丹病毒病食蟹猴模型。
Vaccines (Basel). 2022 Oct 15;10(10):1723. doi: 10.3390/vaccines10101723.
7
Development and Characterization of a Guinea Pig-Adapted Sudan Virus.一种豚鼠适应株苏丹病毒的研制与特性分析
J Virol. 2015 Oct 21;90(1):392-9. doi: 10.1128/JVI.02331-15. Print 2016 Jan 1.
8
STAT-1 Knockout Mice as a Model for Wild-Type Sudan Virus (SUDV).STAT-1 敲除小鼠作为野生型苏丹病毒（SUDV）的模型。
Viruses. 2021 Jul 17;13(7):1388. doi: 10.3390/v13071388.
9
Venezuelan equine encephalitis virus replicon particle vaccine protects nonhuman primates from intramuscular and aerosol challenge with ebolavirus.委内瑞拉马脑炎病毒复制子颗粒疫苗可保护非人灵长类动物免受埃博拉病毒的肌肉内和呼吸道挑战。
J Virol. 2013 May;87(9):4952-64. doi: 10.1128/JVI.03361-12. Epub 2013 Feb 13.
10
Lessons Learned from Sudan Ebola Virus Disease (SUDV) Preparedness in Rwanda: A Comprehensive Review and Way Forward.从卢旺达的苏丹埃博拉病毒病（SUDV）防备中吸取的教训：全面审查和前进道路。
J Epidemiol Glob Health. 2023 Sep;13(3):528-538. doi: 10.1007/s44197-023-00133-0. Epub 2023 Jun 28.

引用本文的文献

1
African swine fever virus: Virology, pathogenesis, clinical impact, and global control strategies.非洲猪瘟病毒：病毒学、发病机制、临床影响及全球防控策略
Vet World. 2025 Jun;18(6):1599-1613. doi: 10.14202/vetworld.2025.1599-1613. Epub 2025 Jun 16.
2
Sudan Virus Persistence in Immune-Privileged Organs of Nonhuman Primate Survivors.苏丹病毒在非人灵长类动物幸存者免疫赦免器官中的持续存在。
Emerg Infect Dis. 2025 Feb;31(2):275-280. doi: 10.3201/eid3102.240983.
3
Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.

本文引用的文献

1
Natural history of infection in rhesus and cynomolgus macaques.恒河猴和食蟹猴感染的自然史。
Emerg Microbes Infect. 2022 Dec;11(1):1635-1646. doi: 10.1080/22221751.2022.2086072.
2
Current state of Ebola virus vaccines: A snapshot.埃博拉病毒疫苗的现状：简要概述
PLoS Pathog. 2021 Dec 9;17(12):e1010078. doi: 10.1371/journal.ppat.1010078. eCollection 2021 Dec.
3
Selection of Filovirus Isolates for Vaccine Development Programs.用于疫苗研发项目的丝状病毒分离株的选择
新发和再发传染病：全球趋势及预防和控制新策略。
Signal Transduct Target Ther. 2024 Sep 11;9(1):223. doi: 10.1038/s41392-024-01917-x.
4
An update on nonhuman primate usage for drug and vaccine evaluation against filoviruses.关于用于评估抗丝状病毒药物和疫苗的非人类灵长类动物使用的最新进展。
Expert Opin Drug Discov. 2024 Oct;19(10):1185-1211. doi: 10.1080/17460441.2024.2386100. Epub 2024 Aug 18.
5
Pathogenicity and virulence of African swine fever virus.非洲猪瘟病毒的致病性和毒力。
Virulence. 2024 Dec;15(1):2375550. doi: 10.1080/21505594.2024.2375550. Epub 2024 Jul 7.
6
Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection.耐热两价丝状病毒疫苗可预防严重和致命的苏丹埃博拉病毒和马尔堡病毒感染。
Vaccine. 2024 Jan 25;42(3):598-607. doi: 10.1016/j.vaccine.2023.12.053. Epub 2023 Dec 28.
7
Developing Vaccines to Improve Preparedness for Filovirus Outbreaks: The Perspective of the USA Biomedical Advanced Research and Development Authority (BARDA).开发疫苗以提高应对丝状病毒爆发的准备能力：美国生物医学高级研究与发展管理局（BARDA）的观点。
Vaccines (Basel). 2023 Jun 19;11(6):1120. doi: 10.3390/vaccines11061120.
8
Approaches to demonstrating the effectiveness of filovirus vaccines: Lessons from Ebola and COVID-19.证明丝状病毒疫苗有效性的方法：来自埃博拉和 COVID-19 的经验教训。
Front Immunol. 2023 Feb 2;14:1109486. doi: 10.3389/fimmu.2023.1109486. eCollection 2023.
9
Species-specific immunogenicity and protective efficacy of a vesicular stomatitis virus-based Sudan virus vaccine: a challenge study in macaques.基于水疱性口炎病毒的苏丹病毒疫苗的种属特异性免疫原性和保护效力：猕猴挑战研究。
Lancet Microbe. 2023 Mar;4(3):e171-e178. doi: 10.1016/S2666-5247(23)00001-0. Epub 2023 Feb 2.
10
Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development.开发一种特征明确的用于支持产品研发的苏丹病毒病食蟹猴模型。
Vaccines (Basel). 2022 Oct 15;10(10):1723. doi: 10.3390/vaccines10101723.
Vaccines (Basel). 2021 Sep 19;9(9):1045. doi: 10.3390/vaccines9091045.
4
Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses.重组蛋白丝状病毒疫苗可保护食蟹猴免受埃博拉、苏丹和马尔堡病毒的感染。
Front Immunol. 2021 Aug 18;12:703986. doi: 10.3389/fimmu.2021.703986. eCollection 2021.
5
Identification and Characterization of Defective Viral Genomes in Ebola Virus-Infected Rhesus Macaques.鉴定和分析埃博拉病毒感染恒河猴缺陷型病毒基因组。
J Virol. 2021 Aug 10;95(17):e0071421. doi: 10.1128/JVI.00714-21.
6
Development of Pandemic Vaccines: ERVEBO Case Study.大流行疫苗的研发：ERVEBO案例研究。
Vaccines (Basel). 2021 Feb 25;9(3):190. doi: 10.3390/vaccines9030190.
7
Development of a Well-Characterized Rhesus Macaque Model of Ebola Virus Disease for Support of Product Development.开发一种特征明确的埃博拉病毒病恒河猴模型以支持产品研发。
Microorganisms. 2021 Feb 26;9(3):489. doi: 10.3390/microorganisms9030489.
8
Twelve years of SAMtools and BCFtools.SAMtools 和 BCFtools 十二年。
Gigascience. 2021 Feb 16;10(2). doi: 10.1093/gigascience/giab008.
9
Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.埃博拉疫苗的使用：美国免疫实施咨询委员会的建议，2020 年。
MMWR Recomm Rep. 2021 Jan 8;70(1):1-12. doi: 10.15585/mmwr.rr7001a1.
10
Lessons learned from Zaire ebolavirus to help address urgent needs for vaccines against Sudan ebolavirus and Marburg virus.从扎伊尔埃博拉病毒中吸取的经验教训，以帮助满足针对苏丹埃博拉病毒和马尔堡病毒疫苗的迫切需求。
Hum Vaccin Immunother. 2020 Nov 1;16(11):2855-2860. doi: 10.1080/21645515.2020.1741313. Epub 2020 Apr 10.