病例报告：接种阿斯利康 COVID-19 疫苗后出现急性脑炎。
Case report of acute encephalitis following the AstraZeneca COVID-19 vaccine.
机构信息
Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
出版信息
Int J Rheum Dis. 2022 Aug;25(8):950-956. doi: 10.1111/1756-185X.14372. Epub 2022 Jun 23.
Abstract
Coronavirus disease 2019 (COVID-19) vaccines have proven to be safe, effective and life-saving. However, little information is available on the neurological complications of COVID-19 vaccine. Here, we report a case who developed acute encephalomyelitis 1 week after being vaccinated with AstraZeneca COVID-19 vaccine (AZ vaccine). Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was also suspected. After intravenous dexamethasone and subcutaneous fondaparinux therapy, he returned to normal life without neurological sequelae. Four months later, he received Moderna COVID-19 vaccine without any sequelae.
摘要
新型冠状病毒病 2019（COVID-19）疫苗已被证明是安全、有效和救生的。然而，关于 COVID-19 疫苗的神经系统并发症的信息很少。在这里，我们报告了一例在接种阿斯利康 COVID-19 疫苗（AZ 疫苗）后 1 周发生急性脑脊髓炎的病例。还怀疑是佐剂诱发的自身免疫/炎症综合征（ASIA）。静脉注射地塞米松和皮下磺达肝素钠治疗后，他恢复了正常生活，没有神经系统后遗症。四个月后，他接种了 Moderna COVID-19 疫苗，没有任何后遗症。
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3
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Diseases. 2022 Feb 20;10(1):13. doi: 10.3390/diseases10010013.
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