Department of Research and Development, Norwegian Air Ambulance Foundation, Oslo, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
PLoS One. 2022 Jun 24;17(6):e0270598. doi: 10.1371/journal.pone.0270598. eCollection 2022.
Supplemental oxygen is widely administered in trauma patients, often leading to hyperoxia. However, the clinical evidence for providing supplemental oxygen in all trauma patients is scarce, and hyperoxia has been found to increase mortality in some patient populations. Hypovolemia is a common finding in trauma patients, which affects many hemodynamic parameters, but little is known about how supplemental oxygen affects systemic and cerebral hemodynamics during hypovolemia. We therefore plan to conduct an experimental, randomized, double blinded crossover study to investigate the effect of 100% oxygen compared to room air delivered by a face mask with reservoir on systemic and cerebral hemodynamics during simulated hypovolemia in the lower body negative pressure model in 15 healthy volunteers. We will measure cardiac output, stroke volume, blood pressure, middle cerebral artery velocity and tolerance to hypovolemia continuously in all subjects at two visits to investigate whether oxygen affects the cardiovascular response to simulated hypovolemia. The effect of oxygen on the outcome variables will be analyzed with mixed linear regression. Trial registration: The study is registered in the European Union Drug Regulating Authorities Clinical Trials Database (EudraCT, registration number 2021-003238-35).
在创伤患者中广泛给予补充氧气，这通常会导致氧中毒。然而，为所有创伤患者提供补充氧气的临床证据很少，并且已经发现氧中毒会增加某些患者群体的死亡率。低血容量是创伤患者的常见表现，会影响许多血流动力学参数，但对于补充氧气如何在低血容量期间影响全身和脑血流动力学知之甚少。因此，我们计划进行一项实验性、随机、双盲交叉研究，以调查在 15 名健康志愿者的下体负压模型中模拟低血容量期间，通过带有贮气袋的面罩给予 100%氧气与室内空气对全身和脑血流动力学的影响。我们将在两次就诊时连续测量所有受试者的心输出量、每搏量、血压、大脑中动脉速度和对低血容量的耐受能力，以研究氧气是否会影响对模拟低血容量的心血管反应。使用混合线性回归分析氧气对结局变量的影响。试验注册：该研究在欧洲联盟药品监管当局临床试验数据库（EudraCT，注册号 2021-003238-35）中注册。
