[离子对形成对药物药代动力学性质的影响。1. α-甲基棕榈酸对家兔体内奎宁药代动力学的影响]
[The effect of ion pair formation on the pharmacokinetic properties of drugs. 1. The effect of alpha-methylpalmitic acid on the pharmacokinetics of quinine in rabbits].
作者信息
Neubert R, Fürst W, Schneider S, Müller H, Loh H J, Jirka M
出版信息
Pharmazie. 1987 Jan;42(1):29-30.
PMID:3575400
Abstract
The transport of quinine through artificial lipid membranes is significantly increased by use of alpha-methylpalmitinic acid (alpha-MPS). Using rabbits it could be shown that the alpha-MPS causes a significant increase of the mean resistance time (MRT) of quinine. Besides the alpha-MPS causes an increases Cmax and a shorter tmax of the quinine blood levels.
摘要
使用α-甲基棕榈酸（α-MPS）可显著增加奎宁通过人工脂质膜的转运。对兔子的实验表明，α-MPS可显著增加奎宁的平均滞留时间（MRT）。此外，α-MPS还会使奎宁血药浓度的Cmax升高，tmax缩短。
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