Tian Hefeng, Fan Ying, Yang Lei, Hou Sai, Huang Wen, Dong Ruizhi, Li Shaodong, Zhu Xuanrui, Liu Wenlong, Shi Guanghuan, Li Xiaoke, Zhou Shiping, Wang Xiu
Hefeng Tian, MD, is Team Coordinator, The First Hospital of Jilin University, Changchun, Jilin Province, China.
Ying Fan, BD, is Endoscopy Nurse, The First Hospital of Jilin University, Changchun, Jilin Province, China.
Gastroenterol Nurs. 2022;45(6):428-439. doi: 10.1097/SGA.0000000000000664. Epub 2022 Jun 25.
The quality of bowel preparation is an extremely important determinant of colonoscopy results. However, the efficacy of senna regimens in improving bowel cleanliness is uncertain. We conducted a systematic review and meta-analysis to synthesize data on whether using a senna bowel preparation regimen enhances the bowel cleanliness. We searched Web of Science Core Collection, MEDLINE, PubMed, Embase, Cochrane Library, and Scopus databases (from the inception to August 2021). The primary efficacy outcome was bowel cleanliness. Secondary outcomes included patient compliance, tolerance, and adverse events. Eleven trials fulfilled the inclusion criteria (3,343 patients. Overall, we found no significant differences in bowel cleanliness between the senna regimen and other bowel preparation regimens (odds ratio [95% confidence interval]: 1.02 [0.63, 1.67], p = 0.93). There was significant difference in tolerance (odds ratio [95% confidence interval]: 1.66 [1.08, 2.54], p = .02) and compliance (odds ratio [95% confidence interval]: 3.05 [1.42, 6.55], p = .004). The senna regimen yielded a significantly greater proportion of no nausea (odds ratio [95% confidence interval]: 1.84 [1.45, 2.32]) and vomiting (odds ratio [95% confidence interval]: 1.65 [0.81, 3.35]). Compared with other bowel preparation regimens, the senna regimen may be effective and safe in bowel cleaning before colonoscopy, with superior compliance and tolerance.
肠道准备的质量是结肠镜检查结果的一个极其重要的决定因素。然而，番泻叶方案在改善肠道清洁度方面的疗效尚不确定。我们进行了一项系统综述和荟萃分析，以综合关于使用番泻叶肠道准备方案是否能提高肠道清洁度的数据。我们检索了科学网核心合集、MEDLINE、PubMed、Embase、Cochrane图书馆和Scopus数据库（从创建到2021年8月）。主要疗效结果是肠道清洁度。次要结果包括患者的依从性、耐受性和不良事件。11项试验符合纳入标准（3343名患者）。总体而言，我们发现番泻叶方案与其他肠道准备方案在肠道清洁度方面没有显著差异（优势比[95%置信区间]：1.02[0.63，1.67]，p = 0.93）。在耐受性（优势比[95%置信区间]：1.66[1.08，2.54]，p = 0.02）和依从性（优势比[95%置信区间]：3.05[1.42，6.55]，p = 0.004）方面存在显著差异。番泻叶方案产生无恶心（优势比[95%置信区间]：1.84[1.45，2.32]）和呕吐（优势比[95%置信区间]：1.65[0.81，3.35]）的比例显著更高。与其他肠道准备方案相比，番泻叶方案在结肠镜检查前的肠道清洁中可能是有效且安全的，具有更好的依从性和耐受性。
