Metabolic Modifiers for Aquaculture, Agricultural Biotechnology Department, Center for Genetic Engineering and Biotechnology, Málaga, Spain.
Departamento de Biología Celular, Facultad de Ciencias, Universidad de Málaga, Instituto de Biotecnología y Desarrollo Azul, IBYDA, Genética y Fisiología, 29071, Málaga, Spain.
Arch Virol. 2022 Oct;167(10):2041-2047. doi: 10.1007/s00705-022-05504-9. Epub 2022 Jun 27.
Aquaculture constitutes an alternative source for food production and contributes to a reduction in the indiscriminate catching of aquatic organisms in their natural environment. However, high mortality during the larval state remains a challenge in this sector, mainly because of factors such as diet and diseases caused by pathogens. Therefore, growth and health management is a key strategy for sustainable aquaculture. Synthetic growth hormone secretagogues (GHSs) are a family of ligands that can stimulate pituitary growth hormone release as well as the function of ghrelin, contributing to the immune responses in a variety of vertebrates, including fish. The A233 decapeptide is a GHS with a demonstrated impact on growth, immune system function, and antioxidant defense in tilapia fish, but no antiviral activity has been described for this peptide. Here, using an in vitro model (TRG-2 cells) and two in vivo models (sea bream [Sparus aurata]) and zebrafish [Danio rerio]), we demonstrate for the first time the potential antiviral effect of A233 in teleost fish.
水产养殖是食品生产的一种替代来源，有助于减少在自然环境中对水生生物的滥捕滥捞。然而，在幼虫阶段高死亡率仍然是该领域的一个挑战，主要是由于饮食和病原体引起的疾病等因素。因此，生长和健康管理是可持续水产养殖的关键策略。合成生长激素促分泌素（GHSs）是一类配体，可刺激垂体生长激素释放和胃饥饿素的功能，有助于多种脊椎动物（包括鱼类）的免疫反应。A233 十肽是一种 GHS，已被证明对罗非鱼的生长、免疫系统功能和抗氧化防御有影响，但尚未描述该肽对病毒的活性。在这里，我们首次使用体外模型（TRG-2 细胞）和两种体内模型（海鲈[Sparus aurata]和斑马鱼[Danio rerio]）证明了 A233 在硬骨鱼中的潜在抗病毒作用。
