Schütz A, Skerfving S, Christoffersson J O, Tell I
Sci Total Environ. 1987 Mar;61:201-9. doi: 10.1016/0048-9697(87)90367-6.
In active and retired lead workers there was a close correlation between urinary excretion of lead during 6 h after intake of a single oral dose of 0.5 g penicillamine, and the excretion during 24 h. In chelation tests it is thus sufficient to collect urine for only a few hours. There was a close correlation between the amount of chelatable lead and the blood-lead level, as well as the lead level in biopsies of trabecular bone from vertebrae, but there was no association with lead in compact bone, as measured in finger-bone by in vivo X-ray fluorescence. The chelatable lead probably mainly reflects the soft tissue lead pool and a fraction of the trabecular bone lead pool, which has a relatively rapid turnover. It is not a valid indicator of the pool of lead which has slowly accumulated in the compact bone, and it is thus not useful as a time-integrated index of the exposure over a long period of time.
在在职和退休铅作业工人中，单次口服0.5克青霉胺后6小时内尿铅排泄量与24小时内尿铅排泄量之间存在密切相关性。因此，在螯合试验中，仅收集数小时尿液就足够了。可螯合铅量与血铅水平以及椎体小梁骨活检中的铅水平之间存在密切相关性，但与通过体内X射线荧光法在指骨中测量的密质骨中的铅无关联。可螯合铅可能主要反映软组织铅池以及小梁骨铅池的一部分，其周转相对较快。它不是密质骨中缓慢积累的铅池的有效指标，因此不能用作长期接触的时间积分指数。
