Schütz A, Skerfving S, Christoffersson J O, Ahlgren L, Mattson S
Department of Occupational Medicine, University Hospital, Lund, Sweden.
Arch Environ Health. 1987 Nov-Dec;42(6):340-6. doi: 10.1080/00039896.1987.9934356.
Samples of vertebral bone were obtained by skeletal biopsy and lead concentrations were determined by atomic absorption spectroscopy. The median level of lead in bone in 27 active lead workers was 29 micrograms/g wet weight (range 2-155), corresponding to 370 micrograms/g calcium (range 30-1,120). In 9 retired workers, the corresponding levels were 19 micrograms/g (5-76) and 250 micrograms/g calcium (60-700); in 14 reference subjects without occupational exposure, 1.3 micrograms/g (1-4) and 13 micrograms/g calcium (8-40). The bone lead content rose with time of exposure. Comparison of levels in vertebra with those in fingerbone, as measured by in vivo x-ray fluorescence in the same subjects, strongly suggested the presence of lead pools with different kinetics. The accumulation pattern, as well as the relation between levels in vertebra and fingerbone, suggests a much shorter half-time of lead in the mainly trabecular vertebral bone as compared to the mainly cortical fingerbone. Further, there was an association between vertebral and blood lead levels in the retired workers, which shows a considerable endogenous lead exposure from the skeletal pool.
通过骨骼活检获取椎骨样本，并采用原子吸收光谱法测定铅浓度。27名在职铅作业工人的骨铅中位数水平为29微克/克湿重（范围为2 - 155），相当于370微克/克钙（范围为30 - 1120）。9名退休工人的相应水平分别为19微克/克（5 - 76）和250微克/克钙（60 - 700）；14名无职业暴露的对照对象的相应水平分别为1.3微克/克（1 - 4）和13微克/克钙（8 - 40）。骨铅含量随暴露时间增加。对同一受试者通过体内X射线荧光法测量的椎骨和指骨铅水平进行比较，有力地表明存在具有不同动力学的铅池。其蓄积模式以及椎骨和指骨水平之间的关系表明，与主要为皮质骨的指骨相比，主要为小梁骨的椎骨中铅的半衰期要短得多。此外，退休工人的椎骨铅水平与血铅水平之间存在关联，这表明骨骼铅库存在相当程度的内源性铅暴露。
