体内骨铅测量：一种累积铅暴露的快速监测方法。

In vivo bone lead measurements: a rapid monitoring method for cumulative lead exposure.

作者信息

Wielopolski L, Ellis K J, Vaswani A N, Cohn S H, Greenberg A, Puschett J B, Parkinson D K, Fetterolf D E, Landrigan P J

出版信息

Am J Ind Med. 1986;9(3):221-6. doi: 10.1002/ajim.4700090304.

Abstract

Lead concentrations (microgram/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X-ray fluorescence technique. Forty-five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 micrograms/g wet weight (0 to 198 micrograms/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X-ray fluorescence findings and lead excretion following Ca-EDTA administration is 0.69; p less than 0.001.

摘要

采用X射线荧光技术对人体骨骼（胫骨）中的铅浓度（微克/克湿重）进行了无创活体测量。45名长期遭受工业铅暴露的工人的骨骼铅平均含量为52.9微克/克湿重（0至198微克/克）。除了骨骼铅含量外，还评估了血铅、经乙二胺四乙酸（EDTA）螯合后通过尿铅排泄评估的铅体内负荷、锌原卟啉以及非刺激性尿铅排泄。结果表明，胫骨铅含量的活体测量可能是衡量体内铅负荷的一个可接受指标，并为铅筛查提供了一种实用技术。X射线荧光检测结果与注射Ca-EDTA后的铅排泄之间的相关系数为0.69；p<0.001。