Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China.
Chin Med Sci J. 2022 Dec 31;37(4):359-362. doi: 10.24920/003999.
Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here, we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis, and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally, she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.
继发于抗中性粒细胞胞质抗体（ANCA）相关性血管炎的肾淀粉样变性极为罕见。本文报道了 1 例 ANCA 相关性血管炎患者。肾活检行 Masson 三色染色显示寡免疫细胞性新月体性肾小球肾炎，电镜显示系膜区有淀粉样物质沉积。免疫荧光显示κ轻链和λ轻链阴性。骨髓活检未见克隆性浆细胞。最终诊断为 ANCA 相关性血管炎继发的肾淀粉样 A 型淀粉样变性。
