School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, No. 2 Xuelin Road, Nanjing 210097, China.
Institute of Biotechnology, RWTH Aachen University, Worringerweg 3, 52074 Aachen, Germany.
Bioresour Technol. 2022 Sep;360:127516. doi: 10.1016/j.biortech.2022.127516. Epub 2022 Jun 25.
Lignocellulosic biomass is an abundant and sustainable raw material, but its conversion into ethanol fuel has not yet achieved large-scale industrialization and economic benefits. Integrated biorefineries have been widely identified as the key to achieving this goal. Here, four promising routes were summarized to assemble the new industrial plants for cellulose-based fuels and chemicals, including 1) integration of cellulase production systems into current cellulosic ethanol processes; 2) combination of processes and facilities between cellulosic ethanol and first-generation ethanol; 3) application of enzyme-free saccharification processes and computational approaches to increase the bioethanol yield and optimize the integration process; 4) production of multiple products to maximize the value derived from the lignocellulosic biomass. Finally, the remaining challenges and perspectives of this field are also discussed.
木质纤维素生物质是一种丰富且可持续的原料，但将其转化为乙醇燃料尚未实现大规模工业化和经济效益。综合生物精炼厂已被广泛认为是实现这一目标的关键。在这里，总结了四种有前途的路线，以组装用于纤维素基燃料和化学品的新型工业工厂，包括 1）将纤维素酶生产系统集成到当前的纤维素乙醇工艺中；2）在纤维素乙醇和第一代乙醇之间结合工艺和设施；3）应用无酶糖化工艺和计算方法来提高生物乙醇产量并优化集成工艺；4）生产多种产品以最大限度地提高木质纤维素生物质的价值。最后，还讨论了该领域的剩余挑战和前景。
