非阿司匹林类非甾体抗炎药在结直肠癌中的应用：临床研究综述。
Non-aspirin non-steroidal anti-inflammatory drugs in colorectal cancer: a review of clinical studies.
机构信息
Department of Medical Oncology, The Alfred Hospital, Alfred Health, Melbourne, VIC, Australia.
School of Public Health and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
出版信息
Br J Cancer. 2022 Nov;127(10):1735-1743. doi: 10.1038/s41416-022-01882-8. Epub 2022 Jun 28.
Abstract
Colorectal cancer (CRC) chemoprevention is an area of interest. Non-steroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory agents which have been identified as cancer chemoprevention agents given that inflammation is thought to contribute to tumorigenesis. Most studies have demonstrated that the NSAID, aspirin, plays a beneficial role in the prevention of CRC and colonic adenomas. Non-aspirin NSAIDs (NA-NSAIDs) have also been studied in CRC chemoprevention. There is increasing literature around their role in pre-cancerous polyp prevention and in decreasing CRC incidence and CRC-related outcomes in certain high-risk subgroups. However, the use of NA-NSAIDs may be accompanied by increased risks of toxicity. Further studies are required to establish the associations between concurrent aspirin and NA-NSAID use, and CRC-related outcomes.
摘要
结直肠癌（CRC）的化学预防是一个研究热点。非甾体类抗炎药（NSAIDs）具有抗炎作用，被认为是癌症化学预防剂，因为炎症被认为有助于肿瘤发生。大多数研究表明，抗炎药阿司匹林在预防 CRC 和结肠腺瘤方面发挥了有益作用。非阿司匹林类 NSAIDs（NA-NSAIDs）也在 CRC 的化学预防中进行了研究。关于它们在癌前息肉预防以及在某些高危亚组中降低 CRC 发病率和与 CRC 相关结局方面的作用，相关文献越来越多。然而，NA-NSAIDs 的使用可能伴随着毒性增加的风险。需要进一步的研究来确定同时使用阿司匹林和 NA-NSAIDs 与 CRC 相关结局之间的关联。
相似文献
1
Non-aspirin non-steroidal anti-inflammatory drugs in colorectal cancer: a review of clinical studies.非阿司匹林类非甾体抗炎药在结直肠癌中的应用：临床研究综述。
Br J Cancer. 2022 Nov;127(10):1735-1743. doi: 10.1038/s41416-022-01882-8. Epub 2022 Jun 28.
2
Chemoprevention of colorectal cancer: systematic review and economic evaluation.结直肠癌的化学预防：系统评价和经济评估。
Health Technol Assess. 2010 Jun;14(32):1-206. doi: 10.3310/hta14320.
3
Aspirin and other nonsteroidal anti-inflammatory agents in the prevention of colorectal cancer.阿司匹林及其他非甾体抗炎药在结直肠癌预防中的应用
Important Adv Oncol. 1996:123-37.
4
Non steroidal anti-inflammatory drugs (NSAID) and Aspirin for preventing colorectal adenomas and carcinomas.非甾体抗炎药（NSAID）和阿司匹林用于预防结直肠腺瘤和癌。
Cochrane Database Syst Rev. 2004;2004(2):CD004079. doi: 10.1002/14651858.CD004079.pub2.
5
Does aspirin or non-aspirin non-steroidal anti-inflammatory drug use prevent colorectal cancer in inflammatory bowel disease?使用阿司匹林或非阿司匹林非甾体抗炎药能否预防炎症性肠病患者患结直肠癌？
World J Gastroenterol. 2016 Apr 7;22(13):3679-86. doi: 10.3748/wjg.v22.i13.3679.
6
Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.阿司匹林和 NSAIDs 对结直肠癌风险和生存的影响。
Gut. 2010 Dec;59(12):1670-9. doi: 10.1136/gut.2009.203000. Epub 2010 Sep 15.
7
Can We Select Patients for Colorectal Cancer Prevention with Aspirin?我们能否选择使用阿司匹林预防结直肠癌的患者？
Curr Pharm Des. 2015;21(35):5127-34. doi: 10.2174/1381612821666150915111000.
8
Non-steroidal anti-inflammatory drugs and molecular carcinogenesis of colorectal carcinomas.非甾体抗炎药与结直肠癌的分子致癌作用
Lancet. 2003 Jul 19;362(9379):230-2. doi: 10.1016/s0140-6736(03)13915-3.
9
Chemoprevention for colon cancer: new opportunities, fact or fiction?结肠癌的化学预防：新机遇，事实还是虚构？
Scand J Gastroenterol Suppl. 2006(243):158-64. doi: 10.1080/00365520600664284.
10
Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.非甾体类抗炎药和环氧化酶-2抑制剂用于结直肠癌的一级预防：为美国预防服务工作组所做的系统评价
Ann Intern Med. 2007 Mar 6;146(5):376-89. doi: 10.7326/0003-4819-146-5-200703060-00010.
引用本文的文献
1
Biomarkers of inflammation and colorectal cancer risk.炎症生物标志物与结直肠癌风险
Front Oncol. 2025 Feb 6;15:1514009. doi: 10.3389/fonc.2025.1514009. eCollection 2025.
2
Triglyceride-glucose index (TyG index) is associated with a higher risk of colorectal adenoma and multiple adenomas in asymptomatic subjects.甘油三酯-葡萄糖指数（TyG 指数）与无症状受试者结直肠腺瘤和多发性腺瘤的风险增加相关。
PLoS One. 2024 Nov 7;19(11):e0310526. doi: 10.1371/journal.pone.0310526. eCollection 2024.
3
Unveiling the intratumoral microbiota within cancer landscapes.揭示癌症微环境中的肿瘤内微生物群。
iScience. 2024 May 3;27(6):109893. doi: 10.1016/j.isci.2024.109893. eCollection 2024 Jun 21.
4
Molecular mechanisms of aging and anti-aging strategies.衰老和抗衰老策略的分子机制。
Cell Commun Signal. 2024 May 24;22(1):285. doi: 10.1186/s12964-024-01663-1.
5
Altered lipid metabolism in APC-driven colorectal cancer: the potential for therapeutic intervention.APC驱动的结直肠癌中脂质代谢的改变：治疗干预的潜力
Front Oncol. 2024 Mar 25;14:1343061. doi: 10.3389/fonc.2024.1343061. eCollection 2024.
6
The Past and Future of Inflammation as a Target to Cancer Prevention.炎症作为癌症预防靶点的过去和未来。
Cancer Prev Res (Phila). 2024 Apr 2;17(4):141-155. doi: 10.1158/1940-6207.CAPR-23-0423.
7
The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling.表达环氧化酶的间充质通过旁分泌信号传导抵抗肠道上皮损伤。
Cell Regen. 2023 Aug 14;12(1):30. doi: 10.1186/s13619-023-00174-7.
8
Non-steroidal anti-inflammatory drugs and biomarkers: A new paradigm in colorectal cancer.非甾体抗炎药与生物标志物：结直肠癌的一种新范式
Front Med (Lausanne). 2023 Mar 6;10:1130710. doi: 10.3389/fmed.2023.1130710. eCollection 2023.
9
Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway.积雪草苷通过 NF-κB 通路增加 MCF-7 细胞中的 Caspase-9 活性并抑制裸鼠异种移植瘤中 TNF-α 和 IL-6 的表达。
Molecules. 2023 Feb 23;28(5):2101. doi: 10.3390/molecules28052101.
10
Unraveling the Complex Interconnection between Specific Inflammatory Signaling Pathways and Mechanisms Involved in HIV-Associated Colorectal Oncogenesis.解析特定炎症信号通路与HIV相关结直肠癌发生机制之间的复杂相互联系。
Cancers (Basel). 2023 Jan 25;15(3):748. doi: 10.3390/cancers15030748.
本文引用的文献
1
Non-steroidal anti-inflammatory drugs, polygenic risk score and colorectal cancer risk.非甾体抗炎药、多基因风险评分与结直肠癌风险。
Aliment Pharmacol Ther. 2021 Jul;54(2):167-175. doi: 10.1111/apt.16438. Epub 2021 Jun 11.
2
Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial.塞来昔布对比安慰剂联合标准辅助治疗对 III 期结肠癌无病生存的影响：CALGB/SWOG 80702（Alliance）随机临床试验。
JAMA. 2021 Apr 6;325(13):1277-1286. doi: 10.1001/jama.2021.2454.
3
Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial.家族性腺瘤性息肉病患者在未接受结肠切除术前行低剂量阿司匹林、美沙拉嗪或两者联合化学预防（J-FAPP 研究 IV）：一项多中心、双盲、随机、两因素、两水平设计试验。
Lancet Gastroenterol Hepatol. 2021 Jun;6(6):474-481. doi: 10.1016/S2468-1253(21)00018-2. Epub 2021 Apr 2.
4
AGA Clinical Practice Update on Chemoprevention for Colorectal Neoplasia: Expert Review.AGA 临床实践更新：结直肠肿瘤的化学预防：专家评论。
Clin Gastroenterol Hepatol. 2021 Jul;19(7):1327-1336. doi: 10.1016/j.cgh.2021.02.014. Epub 2021 Feb 10.
5
Associations of Aspirin and Non-Aspirin Non-Steroidal Anti-Inflammatory Drugs With Colorectal Cancer Mortality After Diagnosis.阿司匹林和非阿司匹林类非甾体抗炎药与诊断后结直肠癌死亡率的相关性。
J Natl Cancer Inst. 2021 Jul 1;113(7):833-840. doi: 10.1093/jnci/djab008.
6
Effect of Aspirin on Cancer Incidence and Mortality in Older Adults.阿司匹林对老年人癌症发病和死亡的影响。
J Natl Cancer Inst. 2021 Mar 1;113(3):258-265. doi: 10.1093/jnci/djaa114.
7
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial.阿司匹林用于遗传性结直肠癌（林奇综合征）的癌症预防：CAPP2 研究的 10 年随访和基于登记的 20 年数据：一项双盲、随机、安慰剂对照试验。
Lancet. 2020 Jun 13;395(10240):1855-1863. doi: 10.1016/S0140-6736(20)30366-4.
8
Aspirin and the risk of colorectal and other digestive tract cancers: an updated meta-analysis through 2019.阿司匹林与结直肠癌和其他消化道癌症风险：更新的荟萃分析至 2019 年。
Ann Oncol. 2020 May;31(5):558-568. doi: 10.1016/j.annonc.2020.02.012. Epub 2020 Apr 1.
9
Perioperative Use of Nonsteroidal Anti-inflammatory Drugs Decreases the Risk of Recurrence of Cancer After Colorectal Resection: A Cohort Study Based on Prospective Data.围手术期使用非甾体抗炎药可降低结直肠切除术后癌症复发的风险：一项基于前瞻性数据的队列研究。
Ann Surg Oncol. 2019 Nov;26(12):3826-3837. doi: 10.1245/s10434-019-07600-8. Epub 2019 Jul 16.
10
Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis.选择性 COX-2 抑制剂联合阿司匹林应用 5 年随访后结直肠癌和心血管血栓栓塞事件的风险：一项荟萃分析。
Colorectal Dis. 2019 Apr;21(4):417-426. doi: 10.1111/codi.14556. Epub 2019 Feb 7.
Zotero 插件