甘油三酯-葡萄糖指数（TyG 指数）与无症状受试者结直肠腺瘤和多发性腺瘤的风险增加相关。

Triglyceride-glucose index (TyG index) is associated with a higher risk of colorectal adenoma and multiple adenomas in asymptomatic subjects.

机构信息

Stanley Ho Big Data Decision Analytics Research Centre, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.

The Nethersole School of Nursing, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.

出版信息

PLoS One. 2024 Nov 7;19(11):e0310526. doi: 10.1371/journal.pone.0310526. eCollection 2024.

DOI:10.1371/journal.pone.0310526

PMID:39509387

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11542827/

Abstract

HYPOTHESIS

The objective of this study is to evaluate the predictive ability of the TyG index for the presence of adenoma and multiple adenomas in an asymptomatic population.

DESIGN

A secondary analysis was conducted on a prospective cohort of asymptomatic subjects aged between 50 and 75 who underwent CRC screening. Fasting blood glucose (FBG) and lipid profiles were measured within three months prior colonoscopy. TyG index was estimated as ln [fasting triglycerides (mg/dL) × FBG (mg/dL)/2]. Multivariate logistic regression was performed to assess the association between the TyG index and the risk of adenoma. Its association with multiple adenomas (≥5) and the continuous number of adenomas were assessed by multinomial regression and log-normal linear regression, respectively.

RESULTS

A total of 1,538 subjects were recruited among which 876 subjects (57%) had at least one adenoma detected. Elevated TyG index was positively associated with the incidence of adenoma (adjusted odds ratio [aOR]: 1.26, 95% confidence interval [CI]: 1.04-1.54). Compared with the lowest TyG index (≤ 8) group, the risk of adenoma was the highest among subjects in the highest TyG index (> 10) group (aOR: 3.36, 95% CI: 1.44-7.73). As compared to the non-adenoma group, the TyG index was also positively associated with multiple adenomas (aOR: 1.74, 95% CI: 1.17-2.57), and the estimate was also the highest in the highest TyG group (aOR: 14.49, 95% CI: 3.12-67.20). As for the number of adenomas, the positive association was maintained (Estimates: 1.06, 95% CI: 1.01-1.12) while the number of adenomas increase the most in the highest TyG index group (Estimates: 1.35, 95% CI: 1.10-1.65).

CONCLUSIONS

Elevated TyG index is associated with an increased risk of colorectal adenoma and an increased number of adenomas for asymptomatic subjects aged ≥50.

TRIAL REGISTRATION

This study was registered on clinicaltrials.gov (NCT03597204 and NCT04034953).

摘要

假设

本研究的目的是评估 TyG 指数在无症状人群中预测腺瘤和多发性腺瘤存在的能力。

设计

对年龄在 50 至 75 岁之间接受 CRC 筛查的无症状受试者的前瞻性队列进行二次分析。在结肠镜检查前三个月内测量空腹血糖 (FBG) 和血脂谱。TyG 指数估计为 ln [空腹甘油三酯 (mg/dL) × FBG (mg/dL)/2]。进行多变量逻辑回归以评估 TyG 指数与腺瘤风险之间的关联。通过多项回归评估其与多发性腺瘤（≥5）的关联，通过对数正态线性回归分别评估与多个腺瘤的关联。

结果

共招募了 1538 名受试者，其中 876 名（57%）至少发现一个腺瘤。升高的 TyG 指数与腺瘤的发生率呈正相关（调整后的优势比[aOR]：1.26，95%置信区间[CI]：1.04-1.54）。与最低 TyG 指数（≤8）组相比，最高 TyG 指数（>10）组的腺瘤风险最高（aOR：3.36，95%CI：1.44-7.73）。与非腺瘤组相比，TyG 指数也与多发性腺瘤呈正相关（aOR：1.74，95%CI：1.17-2.57），最高 TyG 组的估计值也最高（aOR：14.49，95%CI：3.12-67.20）。对于腺瘤数量，这种正相关仍然存在（估计值：1.06，95%CI：1.01-1.12），而在最高 TyG 指数组中，腺瘤数量增加最多（估计值：1.35，95%CI：1.10-1.65）。