Department of Biomedical Engineering, New Jersey Institute of Technology, University Height, Newark, NJ, 07102, USA.
School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, People's Republic of China.
Brain Struct Funct. 2022 Sep;227(7):2299-2312. doi: 10.1007/s00429-022-02522-w. Epub 2022 Jun 29.
Spatially remote brain regions show synchronized activity as typically revealed by correlated functional MRI (fMRI) signals. An emerging line of research has focused on the temporal fluctuations of connectivity; however, its relationships with stationary connectivity have not been clearly illustrated. We examined dynamic and stationary connectivity when the participants watched four different movie clips. We calculated point-by-point multiplication between two regional time series to estimate the time-resolved dynamic connectivity, and estimated the inter-individual consistency of the dynamic connectivity time series. Widespread consistent dynamic connectivity was observed for each movie clip, which also showed differences between the clips. For example, a cartoon movie clip, Wall-E, showed more consistent of dynamic connectivity with the posterior cingulate cortex and supramarginal gyrus, while a court drama clip, A Few Good Men, showed more consistent of dynamic connectivity with the auditory cortex and temporoparietal junction, which might suggest the involvement of specific brain processing for different movie contents. In contrast, the stationary connectivity as measured by the correlations between regional time series was highly similar among the movie clips, and showed fewer statistically significant differences. The patterns of consistent dynamic connectivity could be used to classify different movie clips with higher accuracy than the stationary connectivity and regional activity. These results support the functional significance of dynamic connectivity in reflecting functional brain changes, which could provide more functionally relevant information than stationary connectivity.
空间上遥远的脑区表现出同步活动，这通常可以通过相关的功能磁共振成像 (fMRI) 信号揭示。新兴的研究方向集中在连接的时间波动上；然而，其与静止连接的关系尚未得到清晰说明。当参与者观看四个不同的电影片段时，我们检查了动态和静态连接。我们计算了两个区域时间序列之间的逐点乘法，以估计时间分辨的动态连接，并估计了动态连接时间序列的个体间一致性。对于每个电影片段都观察到了广泛一致的动态连接，这些片段之间也存在差异。例如，一部卡通电影《Wall-E》显示出与后扣带回皮质和缘上回之间更一致的动态连接，而一部法庭剧《A Few Good Men》则显示出与听觉皮质和颞顶联合之间更一致的动态连接，这可能表明不同的电影内容涉及特定的大脑处理。相比之下，通过区域时间序列之间的相关性测量的静态连接在电影片段之间非常相似，并且统计学差异较小。一致的动态连接模式可以比静态连接和区域活动更准确地对不同的电影片段进行分类。这些结果支持动态连接在反映功能大脑变化方面的功能意义，它可以提供比静态连接更具功能相关性的信息。
