School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China
BMJ Open. 2022 Jun 29;12(6):e062183. doi: 10.1136/bmjopen-2022-062183.
To evaluate the global burden of musculoskeletal (MSK) disorders, as well as the five common conditions, and their relevant risk factors from 1990 to 2019.
Data from the Global Burden of Disease Study 2019 were used in this study.
Individuals of all ages and genders from 204 countries and territories in 21 regions.
The outcomes were the numbers and age-standardised rates (ASRs) of incident cases, deaths and disability-adjusted life-years (DALYs) of MSK disorders. The average annual percent changes (AAPCs) in the ASRs were calculated using joinpoint regression analysis to estimate the trends.
There were 322.75 million incident cases, 117.54 thousand deaths and 150.08 million DALYs of MSK disorders in 2019. The age-standardised incidence rate and age-standardised DALY rate in 2019 (incidence: AAPC=-0.32, 95% CI -0.34 to -0.31; DALYs: AAPC=-0.05, 95% CI -0.06 to -0.04) were lower than those in 1990. However, the age-standardised death rate showed a stable trend (AAPC 0.05, 95% CI -0.05 to 0.15) from 1990 to 2019. The peak age of onset and DALYs of MSK disorders was 50-54 years in 2019. The burden of MSK disorders in females was much higher than that in males (1.29 times more incident cases, 2.24 times more deaths and 1.45 times more DALYs in females than in males). A significant negative correlation was observed between the AAPCs in the ASRs and the Sociodemographic Index (SDI) score. Occupational risk exhibited the highest contribution to MSK disorders, and tobacco use and high body mass index were also major risk factors.
This study demonstrates that the burden of MSK disorders tends to be lower in high-SDI regions than in lower-SDI regions. Strengthening the effectiveness of preventive measures against occupational risks may reduce the burden of MSK disorders.
评估全球肌肉骨骼（MSK）疾病的负担，以及五种常见疾病及其相关危险因素，时间范围为 1990 年至 2019 年。
本研究使用了 2019 年全球疾病负担研究的数据。
来自 21 个地区的 204 个国家和地区的所有年龄和性别的个体。
结局指标为 MSK 疾病的发病例数、死亡人数和伤残调整生命年（DALY），以及 MSK 疾病的年龄标准化发病率（ASR）和年龄标准化死亡率（ASD）。使用 joinpoint 回归分析计算 ASR 的年均百分比变化（AAPC），以估计趋势。
2019 年，MSK 疾病的发病例数为 3.2275 亿例，死亡人数为 11.75 千例，伤残调整生命年（DALY）为 1.5008 亿例。2019 年的年龄标准化发病率（AAPC=-0.32，95%CI-0.34 至-0.31）和年龄标准化 DALY 率（AAPC=-0.05，95%CI-0.06 至-0.04）均低于 1990 年。然而，1990 年至 2019 年，年龄标准化死亡率呈稳定趋势（AAPC0.05，95%CI-0.05 至 0.15）。2019 年，MSK 疾病的发病高峰年龄和 DALY 为 50-54 岁。女性的 MSK 疾病负担远高于男性（女性的发病例数比男性多 1.29 倍，死亡人数比男性多 2.24 倍，DALY 比男性多 1.45 倍）。MSK 疾病 ASR 的 AAPC 与社会人口指数（SDI）得分呈显著负相关。职业风险是 MSK 疾病的最大贡献因素，而烟草使用和高身体质量指数也是主要危险因素。
本研究表明，高 SDI 地区的 MSK 疾病负担往往低于低 SDI 地区。加强职业风险预防措施的有效性可能会降低 MSK 疾病的负担。
