Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, USA
School of Nursing and Health Studies, University of Miami, Coral Gables, Florida, USA.
BMJ Open. 2022 Jun 28;12(6):e061248. doi: 10.1136/bmjopen-2022-061248.
Exposure to gender-based violence (GBV) and violence against children (VAC) can result in substantial morbidity and mortality. Previous reviews of health outcomes associated with GBV and VAC have focused on limited definitions of exposure to violence (ie, intimate partner violence) and often investigate associations only with predefined health outcomes. In this protocol, we describe a systematic review and meta-analysis for a comprehensive assessment of the impact of violence exposure on health outcomes and health-related risk factors across the life-course.
Electronic databases (PubMed, Embase, CINAHL, PsycINFO, Global Index Medicus, Cochrane and Web of Science Core Collection) will be searched from 1 January 1970 to 30 September 2021 and searches updated to the current date prior to final preparation of results. Reviewers will first screen titles and abstracts, and eligible articles will then be full-text screened and accepted should they meet all inclusion criteria. Data will be extracted using a standardised form with fields to capture study characteristics and estimates of association between violence exposure and health outcomes. Individual study quality will be assessed via six risk of bias criteria. For exposure-outcome pairs with sufficient data, evidence will be synthesised via a meta-regression-Bayesian, regularised, trimmed model and confidence in the cumulative evidence assessed via the burden of proof risk function. Where possible, variations in associations by subgroup, that is, age, sex or gender, will be explored.
Formal ethical approval is not required. Findings from this review will be used to inform improved estimation of GBV and VAC within the Global Burden of Disease Study. The review has been undertaken in conjunction with the Lancet Commission on GBV and the Maltreatment of Young People with the aim of providing new data insights for a report on the global response to violence.
CRD42022299831.
接触基于性别的暴力（GBV）和暴力侵害儿童（VAC）会导致大量的发病率和死亡率。以前对与 GBV 和 VAC 相关的健康结果的审查侧重于对暴力的有限定义（即亲密伴侣暴力），并且通常仅调查与预定义健康结果的关联。在本方案中，我们描述了一项系统评价和荟萃分析，以全面评估一生中暴露于暴力对健康结果和与健康相关的危险因素的影响。
从 1970 年 1 月 1 日至 2021 年 9 月 30 日，将在电子数据库（PubMed、Embase、CINAHL、PsycINFO、全球索引医学、Cochrane 和 Web of Science 核心合集）中进行搜索，并在最终准备结果之前更新到当前日期的搜索。审查员将首先筛选标题和摘要，符合条件的文章将全文筛选，如果符合所有纳入标准，则将被接受。将使用标准表格提取数据，该表格包含捕获研究特征和暴力暴露与健康结果之间关联估计的字段。通过六个偏倚风险标准评估单个研究的质量。对于具有足够数据的暴露-结果对，将通过贝叶斯、正则化、修剪模型的元回归和通过证明负担风险函数评估累积证据的置信度来综合证据。在可能的情况下，将按年龄、性别或性别等亚组探索关联的变化。
不需要正式的伦理批准。本综述的结果将用于改进全球疾病负担研究中对 GBV 和 VAC 的估计。本综述是与柳叶刀委员会对 GBV 和虐待年轻人的合作进行的，目的是为全球对暴力的应对措施报告提供新的数据见解。
PROSPERO 注册号：CRD42022299831。
