Waseda Institute for Advanced Study, Waseda University, Tokyo 1690051, Japan.
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 2770882, Japan.
Bioinformatics. 2022 Aug 10;38(16):4039-4041. doi: 10.1093/bioinformatics/btac433.
We present Mirage 2.0, which accurately estimates gene-content evolutionary history by considering heterogeneous evolutionary patterns among gene families. Notably, we introduce a deterministic pattern mixture model, which makes Mirage substantially faster and more memory-efficient to be applicable to large datasets with thousands of genomes.
The source code is freely available at https://github.com/fukunagatsu/Mirage.
Supplementary data are available at Bioinformatics online.
我们提出了 Mirage 2.0,它通过考虑基因家族之间的异构进化模式,准确地估计基因内容的进化历史。值得注意的是,我们引入了一个确定性模式混合模型,这使得 Mirage 在速度和内存效率方面有了显著的提升,使其能够适用于包含数千个基因组的大型数据集。
源代码可在 https://github.com/fukunagatsu/Mirage 上免费获取。
补充数据可在 Bioinformatics 在线获取。