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Pathogenic prion structures at high resolution.

作者信息

Caughey Byron, Standke Heidi G, Artikis Efrosini, Hoyt Forrest, Kraus Allison

机构信息

Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, United States of America.

Department of Pathology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America.

出版信息

PLoS Pathog. 2022 Jun 30;18(6):e1010594. doi: 10.1371/journal.ppat.1010594. eCollection 2022 Jun.

DOI:10.1371/journal.ppat.1010594
PMID:35771767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9246223/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0542/9246223/fbbd298f5e92/ppat.1010594.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0542/9246223/6668701cdef4/ppat.1010594.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0542/9246223/fbbd298f5e92/ppat.1010594.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0542/9246223/6668701cdef4/ppat.1010594.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0542/9246223/fbbd298f5e92/ppat.1010594.g002.jpg

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Nat Struct Mol Biol. 2022 Oct;29(10):962-965. doi: 10.1038/s41594-022-00833-4. Epub 2022 Sep 12.
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Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains.无锚定 RML 朊病毒的低温电子显微镜结构揭示了不同株之间共享基序的变化。
Nat Commun. 2022 Jul 13;13(1):4005. doi: 10.1038/s41467-022-30458-6.
3
2.7 Å cryo-EM structure of ex vivo RML prion fibrils.
PLoS Pathog. 2024 Jun 13;20(6):e1012253. doi: 10.1371/journal.ppat.1012253. eCollection 2024 Jun.
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Recent advances in infectious disease research using cryo-electron tomography.利用冷冻电子断层扫描技术进行传染病研究的最新进展。
Front Mol Biosci. 2024 Jan 15;10:1296941. doi: 10.3389/fmolb.2023.1296941. eCollection 2023.
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Acta Neuropathol Commun. 2023 Sep 7;11(1):145. doi: 10.1186/s40478-023-01640-8.
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Reactive astrocytes associated with prion disease impair the blood brain barrier.与朊病毒病相关的反应性星形胶质细胞会损害血脑屏障。
Neurobiol Dis. 2023 Sep;185:106264. doi: 10.1016/j.nbd.2023.106264. Epub 2023 Aug 18.
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Phospholipid cofactor solubilization inhibits formation of native prions.磷脂辅因子溶解抑制天然朊病毒的形成。
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bioRxiv. 2023 Mar 24:2023.03.21.533684. doi: 10.1101/2023.03.21.533684.
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Acta Neuropathol Commun. 2023 Feb 14;11(1):28. doi: 10.1186/s40478-023-01512-1.
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