Liu Baoyi, Li Ang, Xu Jingkai, Cui Yong
Department of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Surg. 2022 Jun 14;9:935107. doi: 10.3389/fsurg.2022.935107. eCollection 2022.
The skin is the outermost barrier of the body. It has developed a sophisticated system against the ever-changing environment. The application of single-cell technologies has revolutionized dermatology research and unraveled the changes and interactions across skin resident cells in the healthy and inflamed skin. Single-cell technologies have revealed the critical roles of stromal cells in an inflammatory response and explained a series of plausible previous findings concerning skin immunity. Here, we summarized the functional diversity of skin stromal cells defined by single-cell analyses and how these cells orchestrated events leading to inflammatory diseases, including atopic dermatitis, psoriasis, vitiligo, and systemic lupus erythematosus.
皮肤是人体最外层的屏障。它已经形成了一套复杂的系统来抵御不断变化的环境。单细胞技术的应用彻底改变了皮肤病学研究，并揭示了健康皮肤和炎症皮肤中皮肤驻留细胞的变化及相互作用。单细胞技术揭示了基质细胞在炎症反应中的关键作用，并解释了一系列先前关于皮肤免疫的看似合理的发现。在此，我们总结了通过单细胞分析定义的皮肤基质细胞的功能多样性，以及这些细胞如何协调导致炎症性疾病（包括特应性皮炎、银屑病、白癜风和系统性红斑狼疮）的事件。
